Detection of focal cortical dysplasia: Development and multicentric evaluation of artificial intelligence models.

Journal: Epilepsia
PMID: 39739580

Abstract

OBJECTIVE: Focal cortical dysplasia (FCD) is a common cause of drug-resistant focal epilepsy but can be challenging to detect visually on magnetic resonance imaging. Three artificial intelligence models for automated FCD detection are publicly available (MAP18, deepFCD, MELD) but have only been compared on single-center data. Our first objective is to compare them on independent multicenter test data. Additionally, we train and compare three new models and make them publicly available.

Authors

  • Lennart N Kersting
    Department of Neuroradiology, University Hospital Bonn, Bonn, Germany.
  • Lennart Walger
    Department of Neuroradiology, University Hospital Bonn, Bonn, Germany.
  • Tobias Bauer
    Department of Neuroradiology, University Hospital Bonn, Bonn, Germany.
  • Vadym Gnatkovsky
    Department of Epileptology, University Hospital Bonn, Bonn, Germany.
  • Fabiane Schuch
    Department of Epileptology, University Hospital Bonn, Bonn, Germany.
  • Bastian David
    Department of Epileptology, University Hospital Bonn, Bonn, Germany.
  • Elisabeth Neuhaus
    Department of Neuroradiology, Goethe University Frankfurt, Frankfurt am Main, Germany.
  • Fee Keil
    Department of Neuroradiology, Goethe University Frankfurt, Frankfurt am Main, Germany.
  • Anna Tietze
    From the Department of Clinical Medicine, Center of Functionally Integrative Neuroscience and MINDLAB, Aarhus University, Denmark (A.N., M.B.H., A.T., K.M.).
  • Felix Rosenow
    Department of Neurology, Epilepsy Center Frankfurt Rhine-Main, Goethe University Frankfurt, Frankfurt am Main, Germany.
  • Angela M Kaindl
    Charité-Universitätsmedizin Berlin, Department of Pediatric Neurology, Berlin, Germany.
  • Elke Hattingen
    Department of Neuroradiology, Johann Wolfgang Goethe University, Frankfurt, Germany.
  • Hans-Jürgen Huppertz
    Swiss Epilepsy Centre, Klinik Lengg, Zurich, Switzerland.
  • Alexander Radbruch
    Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany; Department of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Rainer Surges
    Department of Epileptology, University Hospital Bonn, Bonn, Germany.
  • Theodor Rüber
    Department of Epileptology, University Hospital Bonn, Bonn, Germany.

Keywords

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