Accurate prediction of bleeding risk after coronary artery bypass grafting with dual antiplatelet therapy: A machine learning model vs. the PRECISE-DAPT score.

Journal: International journal of cardiology
PMID:

Abstract

BACKGROUND: Dual antiplatelet therapy (DAPT) after coronary artery bypass grafting (CABG), although might be protective for ischemic events, can lead to varying degrees of bleeding, resulting in serious clinical events, including death. This study aims to develop accurate and scalable predictive tools for early identification of bleeding risks during the DAPT period post-CABG, comparing them with the PRECISE-DAPT score.

Authors

  • Yi Yang
    Department of Orthopedics, Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
  • Yuqing Yan
    School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, China.
  • Zhou Zhou
  • Jifan Zhang
    Nanjing Foreign Language School, Nanjing 210008, China.
  • Haolong Han
    Department of Pharmacy, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, Nanjing 210008, China.
  • Weihui Zhang
    Department of Pharmacy, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China; School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
  • Xia Wang
    Department of Neurology, The Sixth People's Hospital of Huizhou City, Huizhou, China.
  • Chen Chen
    The George Institute for Global Health, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.
  • Weihong Ge
    Department of Pharmacy, Nanjing Drum Tower Hospital Nanjing China.
  • Jun Pan
    Key Laboratory for Biorheological Science and Technology of Ministry of Education, State and Local Joint Engineering Laboratory for Vascular Implants, College of Bioengineering, Chongqing University, Chongqing, China. Electronic address: panj@cqu.edu.cn.
  • Jianjun Zou
    School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, China; Department of Clinical Pharmacology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
  • Hang Xu
    School of Electrical and Electronic Engineering, Nanyang Technological University, Singapore 639798, Singapore. hxu011@e.ntu.edu.sg.