DeepMiRBP: a hybrid model for predicting microRNA-protein interactions based on transfer learning and cosine similarity.
Journal:
BMC bioinformatics
PMID:
39695955
Abstract
BACKGROUND: Interactions between microRNAs and RNA-binding proteins are crucial for microRNA-mediated gene regulation and sorting. Despite their significance, the molecular mechanisms governing these interactions remain underexplored, apart from sequence motifs identified on microRNAs. To date, only a limited number of microRNA-binding proteins have been confirmed, typically through labor-intensive experimental procedures. Advanced bioinformatics tools are urgently needed to facilitate this research.