NERVE 2.0: boosting the new enhanced reverse vaccinology environment via artificial intelligence and a user-friendly web interface.

Journal: BMC bioinformatics
PMID: 39695945

Abstract

BACKGROUND: Vaccines development in this millennium started by the milestone work on Neisseria meningitidis B, reporting the invention of Reverse Vaccinology (RV), which allows to identify vaccine candidates (VCs) by screening bacterial pathogens genome or proteome through computational analyses. When NERVE (New Enhanced RV Environment), the first RV software integrating tools to perform the selection of VCs, was released, it prompted further development in the field. However, the problem-solving potential of most, if not all, RV programs is still largely unexploited by experimental vaccinologists that impaired by somehow difficult interfaces, requiring bioinformatic skills.

Authors

  • Andrea Conte
    Synthetic Biology and Biotechnology Unit, Department of Biology, University of Padua, Padua, Italy.
  • Nicola Gulmini
    Synthetic Biology and Biotechnology Unit, Department of Biology, University of Padua, Padua, Italy.
  • Francesco Costa
    Department of Neurosurgery, Humanitas Research Hospital, Rozzano, Italy.
  • Matteo Cartura
    Synthetic Biology and Biotechnology Unit, Department of Biology, University of Padua, Padua, Italy.
  • Felix Bröhl
    Bröhl Software Development, Bonn, Germany.
  • Francesco Patanè
    Synthetic Biology and Biotechnology Unit, Department of Biology, University of Padua, Padua, Italy.
  • Francesco Filippini
    Synthetic Biology and Biotechnology Unit, Department of Biology, University of Padua, Padua, Italy. francesco.filippini@unipd.it.

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