A Machine Learning Model to Predict De Novo Hepatocellular Carcinoma Beyond Year 5 of Antiviral Therapy in Patients With Chronic Hepatitis B.

Journal: Liver international : official journal of the International Association for the Study of the Liver
PMID:

Abstract

BACKGROUND AND AIMS: This study aims to develop and validate a machine learning (ML) model predicting hepatocellular carcinoma (HCC) in chronic hepatitis B (CHB) patients after the first 5 years of entecavir (ETV) or tenofovir (TFV) therapy.

Authors

  • Yeonjung Ha
    Department of Gastroenterology, CHA Bundang Medical Center, CHA University, Seongnam-si, Gyeonggi-do, South Korea.
  • Seungseok Lee
    Department of Biomedical Engineering, Kyung Hee University, Yong-in, Republic of Korea.
  • Jihye Lim
    Department of Healthcare Management, Youngsan University, Yangsan 626-790, Korea. limjiart@ysu.ac.kr.
  • Kwanjoo Lee
    Department of Gastroenterology, CHA Bundang Medical Center, CHA University, Seongnam-si, Gyeonggi-do, South Korea.
  • Young Eun Chon
    Department of Gastroenterology, CHA Bundang Medical Center, CHA University, Seongnam-si, Gyeonggi-do, South Korea.
  • Joo Ho Lee
    Department of Radiation Oncology and Cancer Research Institute, Seoul National University Hospital, Seoul, Korea.
  • Kwan Sik Lee
    Department of Gastroenterology, CHA Bundang Medical Center, CHA University, Seongnam-si, Gyeonggi-do, South Korea.
  • Kang Mo Kim
    Department of Gastroenterology, Asan Liver Center, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Korea. kimkm70@amc.seoul.kr.
  • Ju Hyun Shim
    Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
  • Danbi Lee
    Department of Gastroenterology, Asan Liver Center, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Korea.
  • Dong Keon Yon
    Center for Digital Health, Medical Science Research Institute, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, South Korea.
  • Jinseok Lee
  • Han Chu Lee
    Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.