Unsupervised Bayesian generation of synthetic CT from CBCT using patient-specific score-based prior.

Journal: Medical physics
Published Date: Dec 12, 2024

Abstract

BACKGROUND: Cone-beam computed tomography (CBCT) scans, performed fractionally (e.g., daily or weekly), are widely utilized for patient alignment in the image-guided radiotherapy (IGRT) process, thereby making it a potential imaging modality for the implementation of adaptive radiotherapy (ART) protocols. Nonetheless, significant artifacts and incorrect Hounsfield unit (HU) values hinder their application in quantitative tasks such as target and organ segmentations and dose calculation. Therefore, acquiring CT-quality images from the CBCT scans is essential to implement online ART in clinical settings.

Authors

  • Junbo Peng
    Nuclear and Radiological Engineering and Medical physics Programs, George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, United States of America.
  • Yuan Gao
    Engineering Research Center of EMR and Intelligent Expert System, Ministry of Education, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou Zhejiang Province, China.
  • Chih-Wei Chang
    Department of Radiation Oncology and Winship Cancer Institute, Emory University, Atlanta, GA 30308, United States of America.
  • Richard Qiu
    Department of Radiation Oncology and Winship Cancer Institute, Emory University, Atlanta, Georgia, USA.
  • Tonghe Wang
    Department of Radiation Oncology and Winship Cancer Institute, Emory University, Atlanta, GA 30322.
  • Aparna Kesarwala
    Department of Radiation Oncology and Winship Cancer Institute, Emory University, Atlanta, Georgia, USA.
  • Kailin Yang
    Department of Radiation Oncology, Taussig Cancer Center, Cleveland Clinic, Cleveland, Ohio, USA.
  • Jacob Scott
    Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH.
  • David Yu
    Department of Radiation Oncology and Winship Cancer Institute, Emory University, Atlanta, Georgia, USA.
  • Xiaofeng Yang
    Department of Radiation Oncology and Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA.

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