A histopathology-based artificial intelligence system assisting the screening of genetic alteration in intrahepatic cholangiocarcinoma.

Journal: British journal of cancer
PMID:

Abstract

BACKGROUND: Targeted therapy for intrahepatic cholangiocarcinoma (ICC) shows superior survival outcomes but patients with certain targetable alterations are no more than 20%. Genetic alteration screening for all ICC patients is of high cost and not routinely performed. This study intends to develop a histopathology-based artificial intelligence (AI)-assisted system for predicting genetic alteration of ICC.

Authors

  • Han Xiao
    Department of Radiation Oncology, Zhongshan Hospital, Fudan University, Shanghai, China.
  • Jianping Wang
    Department of Computer Science, City University of Hong Kong, 83 Tat Chee Ave, Kowloon Tong, Hong Kong, China. jianwang@cityu.edu.hk.
  • Zongpeng Weng
    Clinical Trials Unit, the First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China.
  • Xiaoxuan Lin
    Department of Gastroenterology and Hepatology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
  • Man Shu
    Department of Pathology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
  • Jingxian Shen
    Department of Radiology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangzhou, China.
  • Peng Sun
    Department of Microelectronics, Nankai University, Tianjin, 300350, PR China.
  • Muyan Cai
  • Xiao Xiang
    Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.
  • Bin Li
    Department of Magnetic Resonance Imaging (MRI), Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
  • Lihong Wei
    Department of Pathology, the First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China.
  • Yiyu Shi
    University of Notre Dame.
  • Jiaming Lai
    Center of Hepato‑Pancreato‑Biliary Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
  • Ming Kuang
    School of Medicine, Jiangsu University, Zhenjiang 212013, China.
  • Jingping Yun
    Department of Pathology, Sun Yat-sen University Cancer Center, Guangzhou, China.
  • Shuling Chen
    Department of Medical Ultrasonics, Institute of Diagnostic and Interventional Ultrasound, the First Affiliated Hospital of Sun Yat-Sen University, No. 58, Zhongshan 2nd Road, Guangzhou, 510080, Guangdong, China. chenshling@mail.sysu.edu.cn.
  • Sui Peng
    Center for Precision Medicine, Sun Yat-sen University, Guangzhou, 510080, China.