Drugs from drugs: New chemical insights into a mature concept.

Journal: Drug discovery today
PMID: 39442750

Abstract

Developing new drugs from marketed ones is a well-established and successful approach in drug discovery. We offer a unified view of this field, focusing on the new chemical aspects of the involved approaches: (a) chemical transformation of the original drugs (late-stage modifications, molecular editing), (b) prodrug strategies, and (c) repurposing as a tool to develop new hits/leads. Special focus is placed on the molecular structure of the drugs and their synthetic feasibility. The combination of experimental advances and new computational approaches, including artificial intelligence methods, paves the way for the evolution of the drugs from drugs concept.

Authors

  • Eloy Lozano Baró
    Laboratory of Medicinal Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona and Institute of Biomedicine UB (IBUB), Av. Joan XXIII, 27-31, 08028 Barcelona, Spain.
  • Federica Catti
    Faculty of Science and Mathematics, Arkansas State University Campus Querétaro, Carretera Estatal 100, km 17.5. C.P. 76270, Municipio de Colón, Estado de Querétaro, Mexico.
  • Carolina Estarellas
  • Ouldouz Ghashghaei
    Laboratory of Medicinal Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona and Institute of Biomedicine UB (IBUB), Av. Joan XXIII, 27-31, 08028 Barcelona, Spain. Electronic address: ghashghaei@ub.edu.
  • Rodolfo Lavilla
    Laboratory of Medicinal Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona and Institute of Biomedicine UB (IBUB), Av. Joan XXIII, 27-31, 08028 Barcelona, Spain. Electronic address: rlavilla@ub.edu.

Keywords

External Resources

Popular Topics
Recent Journals