AIMC Topic: Prodrugs
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Drugs from drugs: New chemical insights into a mature concept.
Drug discovery today
Oct 22, 2024
Developing new drugs from marketed ones is a well-established and successful approach in drug discovery. We offer a unified view of this field, focusing on the new chemical aspects of the involved approaches: (a) chemical transformation of the origin...
Machine Learning-Based Prediction of Reduction Potentials for Pt Complexes.
Journal of chemical information and modeling
Apr 29, 2024
Some of the well-known drawbacks of clinically approved Pt complexes can be overcome using six-coordinate Pt complexes as inert prodrugs, which release the corresponding four-coordinate active Pt species upon reduction by cellular reducing agents. Th...
Assessing and utilizing esterase specificity in antimicrobial prodrug development.
Methods in enzymology
Dec 23, 2021
As a class of enzymes, esterases have been investigated for decades and have found use in industrial processes, synthetic organic chemistry, and elsewhere. Esters are functional groups composed of an alcohol moiety and a carboxylic acid moiety. Altho...
Design, preparation and characterization of pH-responsive prodrug micelles with hydrolyzable anhydride linkages for controlled drug delivery.
Journal of colloid and interface science
Dec 31, 2016
We report a new prodrug micelle-based approach in which a model hydrophobic non-steroidal anti-inflammatory drug (NSAID), ibuprofen (Ibu), is tethered to amphiphilic methoxy polyethylene glycol-polypropylene fumarate (mPEG-PPF) diblock copolymer via ...
Micelles
Prodrugs
Drug Liberation
Polypropylenes
Surface Properties
HeLa Cells
Hydrophobic and Hydrophilic Interactions
Hydrogen-Ion Concentration
Polyethylene Glycols
Hydrolysis
Solubility
Anti-Inflammatory Agents, Non-Steroidal
Rabbits
Drug Carriers
Animals
Nanoparticles
Humans
Cell Line
Cell Survival
Ibuprofen
Anhydrides
Fumarates
Simultaneous delivery of anti-miR21 with doxorubicin prodrug by mimetic lipoprotein nanoparticles for synergistic effect against drug resistance in cancer cells.
International journal of nanomedicine
Dec 30, 2016
The development of drug resistance in cancer cells is one of the major obstacles to achieving effective chemotherapy. We hypothesized that the combination of a doxorubicin (Dox) prodrug and microRNA (miR)21 inhibitor might show synergistic antitumor ...
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