Distance guided generative adversarial network for explainable medical image classifications.

Journal: Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society
Published Date:

Abstract

Despite the potential benefits of data augmentation for mitigating data insufficiency, traditional augmentation methods primarily rely on prior intra-domain knowledge. On the other hand, advanced generative adversarial networks (GANs) generate inter-domain samples with limited variety. These previous methods make limited contributions to describing the decision boundaries for binary classification. In this paper, we propose a distance-guided GAN (DisGAN) that controls the variation degrees of generated samples in the hyperplane space. Specifically, we instantiate the idea of DisGAN by combining two ways. The first way is vertical distance GAN (VerDisGAN) where the inter-domain generation is conditioned on the vertical distances. The second way is horizontal distance GAN (HorDisGAN) where the intra-domain generation is conditioned on the horizontal distances. Furthermore, VerDisGAN can produce the class-specific regions by mapping the source images to the hyperplane. Experimental results show that DisGAN consistently outperforms the GAN-based augmentation methods with explainable binary classification. The proposed method can apply to different classification architectures and has the potential to extend to multi-class classification. We provide the code in https://github.com/yXiangXiong/DisGAN.

Authors

  • Xiangyu Xiong
  • Yue Sun
    Department of Rheumatology, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui, China.
  • Xiaohong Liu
    Department of Biopharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Wenhua Road, Shenyang 110016, China. Electronic address: lvj221@163.com.
  • Wei Ke
    Huangshi Public Security Bureau, Huangshi 435000, China.
  • Chan-Tong Lam
    Faculty of Applied Sciences, Macao Polytechnic University, 999078, Macao Special Administrative Region of China.
  • Jiangang Chen
  • Mingfeng Jiang
    School of Information Science and Technology, Zhejiang Sci-Tech University, Hangzhou 310018, People's Republic of China.
  • Mingwei Wang
    College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, People's Republic of China.
  • Hui Xie
    Department of Breast Diseases, The First Affiliated Hospital of Nanjing Medical University & Jiangsu Province Hospital, Nanjing, Jiangsu, China.
  • Tong Tong
    CAS Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China.
  • Qinquan Gao
    College of Physics and Information Engineering, Fuzhou University, Fuzhou 350116, People's Republic of China.
  • Hao Chen
    The First School of Medicine, Wenzhou Medical University, Wenzhou, China.
  • Tao Tan
    Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.