Enhancing individual glomerular filtration rate assessment: can we trust the equation? Development and validation of machine learning models to assess the trustworthiness of estimated GFR compared to measured GFR.

Journal: BMC nephrology
PMID:

Abstract

BACKGROUND: Creatinine-based estimated glomerular filtration rate (eGFR) equations are widely used in clinical practice but exhibit inherent limitations. On the other side, measuring GFR is time consuming and not available in routine clinical practice. We developed and validated machine learning models to assess the trustworthiness (i.e. the ability of equations to estimate measured GFR (mGFR) within 10%, 20% or 30%) of the European Kidney Function Consortium (EKFC) equation at the individual level.

Authors

  • Antoine Lanot
    Normandie Université, Unicaen, CHU de Caen Normandie, Néphrologie, Caen, France.
  • Anna Åkesson
    Clinical Studies Sweden - Forum South, Skåne University Hospital, Lund, Sweden.
  • Felipe Kenji Nakano
    KU Leuven, Campus KULAK - Department of Public Health and Primary Care, Etienne Sabbelaan 53, Kortrijk, 8500, Belgium. felipekenji.nakano@kuleuven.be.
  • Celine Vens
    Department of Computer Science, KU Leuven, Leuven, Belgium.
  • Jonas Björk
    Department of Clinical Sciences, Lund University, Sweden.
  • Ulf Nyman
    Department of Translational Medicine, Division of Medical Radiology, Lund University, Malmö, Sweden.
  • Anders Grubb
    Department of Clinical Chemistry, Skåne University Hospital, Lund University, Lund, Sweden.
  • Per-Ola Sundin
    Karla Healthcare Centre, Faculty of Medicine and Health, Örebro University, 70182, Örebro, SE, Sweden.
  • Björn O Eriksen
    Metabolic and Renal Research Group, UiT the Arctic University of Norway, Tromsö, Norway.
  • Toralf Melsom
    Metabolic and Renal Research Group, UiT the Arctic University of Norway, Tromsö, Norway.
  • Andrew D Rule
    Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA.
  • Ulla Berg
    Department of Clinical Science, Intervention and Technology, Division of Pediatrics, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.
  • Karin Littmann
    Institute om Medicine Huddinge (Med H), Karolinska Institute, Solna, Sweden.
  • Kajsa Åsling-Monemi
    Department of Clinical Science, Intervention and Technology, Division of Pediatrics, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.
  • Magnus Hansson
    Function Area Clinical Chemistry, Karolinska University Laboratory, Karolinska Institute, Karolinska University Hospital Huddinge and Department of Laboratory Medicine, Stockholm, Sweden.
  • Anders Larsson
    5 Hedenstierna Laboratory, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
  • Marie Courbebaisse
    Physiology Department, Georges Pompidou European Hospital, Assistance Publique Hôpitaux de Paris, INSERM U1151-CNRS UMR8253, Paris Descartes University, Paris, France.
  • Laurence Dubourg
    Exploration Fonctionnelle Renale Pavillon P, Hopital Edouard Herriot, 5 Place d'Arsonval, 69437, Lyon, Cedex 03, France.
  • Lionel Couzi
    CNRS-UMR 5164 Immuno ConcEpT, CHU de Bordeaux, Nephrologie-Transplantation-Dialyse, Université de Bordeaux, Bordeaux, France.
  • Francois Gaillard
    Renal Transplantation Department, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.
  • Cyril Garrouste
  • Lola Jacquemont
    Renal Transplantation Department, CHU Nantes, Nantes University, Nantes, France.
  • Nassim Kamar
    Department of Nephrology and Organ Transplantation, CHU Rangueil, Toulouse, France.
  • Christophe Legendre
    Paris Translational Research Centre for Organ Transplantation, INSERM, PARCC, Université de Paris, Paris, France; Kidney Transplant Department, Necker Hospital, Assistance Publique - Hôpitaux de Paris, Paris, France.
  • Lionel Rostaing
    Service de Néphrologie, Hémodialyse, Aphérèses et Transplantation Rénale, Hôpital Michallon, CHU Grenoble-Alpes, Tronche, France.
  • Natalie Ebert
    Institute of Public Health, Charité Universitätsmedizin Berlin, Berlin, Germany.
  • Elke Schaeffner
    Institute of Public Health, Charité Universitätsmedizin Berlin, Berlin, Germany.
  • Arend Bökenkamp
    Department of Paediatric Nephrology, Emma Children's Hospital, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
  • Christophe Mariat
    Service de Néphrologie, Dialyse et Transplantation Rénale, Hôpital Nord, CHU de Saint-Etienne, Saint-Priest-en-Jarez, France.
  • Hans Pottel
    Department of Public Health and Primary Care, KU Leuven Campus Kulak Kortrijk, Kortrijk, Belgium.
  • Pierre Delanaye
    Department of Nephrology-Dialysis-Transplantation, University of Liège (ULg CHU), CHU Sart Tilman, Liège, Belgium.