Annotation-Free Whole-Slide Image Analysis Method to Assess Immune Infiltration in Colorectal Cancer.

Journal: JCO precision oncology
PMID:

Abstract

PURPOSE: Tumor-infiltrating lymphocytes (TILs) play a crucial role in host antitumor processes. High level of TILs is associated with better outcomes for patients. We aim to automatically quantify TILs without any nuclei annotation and further construct an immune score to predict the survival of patients with colorectal cancer.

Authors

  • Yao Xu
    Department of Radiology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.
  • Shangqing Yang
    School of Life Science and Technology, Xidian University, Xian, China.
  • Yaxi Zhu
    Department of Pathology, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
  • Su Yao
    Department of Pathology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.
  • Lin Wu
    Key Laboratory of Grain and Oil Processing and Food Safety of Sichuan Province, College of Food and Bioengineering, Xihua University Chengdu 610039 China xingyage1@163.com.
  • Shenyan Zhang
    Department of Pathology, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
  • Yiting Wang
    Department of Pathology, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
  • Suyun Li
    Department of Radiology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.
  • Yunrui Ye
    Department of Radiology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.
  • Zhenhui Li
    College of Information Sciences and Technology, Pennsylvania State University.
  • Zaiyi Liu
    Department of Radiology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.
  • Ke Zhao
    Department of Radiology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.