New solutions for antibiotic discovery: Prioritizing microbial biosynthetic space using ecology and machine learning.
Journal:
PLoS biology
PMID:
40019875
Abstract
With the explosive increase in genome sequence data, perhaps the major challenge in natural-product-based drug discovery is the identification of gene clusters most likely to specify new chemistry and bioactivities. We discuss the challenges and state-of-the-art of antibiotic discovery based on ecological principles, genome mining and artificial intelligence.