LICEDB: light industrial core enzyme database for industrial applications and AI enzyme design.

Journal: Database : the journal of biological databases and curation
Published Date: Feb 19, 2025

Abstract

Enzymes, serving as eco-friendly catalysts, are progressively supplanting traditional chemical catalysts in light industry sectors such as feed, papermaking, textiles, detergents, leather, and sugar production. Despite this advancement, the variability in the performance of natural enzymes and the fragmentation and diversity of existing data formats pose significant challenges to researchers. Furthermore, AI-driven enzyme design is limited by the quality and quantity of available data. To address these issues, we introduce the light industrial core enzyme database (LICEDB), the first database dedicated exclusively to managing and standardizing enzymes for light industry applications. LICEDB, with its integrated modules for data retrieval, similarity analysis, and structural analysis, will enhance the efficient industrial application of enzymes and strengthen AI-driven predictive research, thereby advancing data sharing and utilization in the field of enzyme innovation. Database URL: http://lujialab.org.cn/on-line-databases/.

Authors

  • Lei Gong
    Qilu Hospital of Shandong University, Department of Endocrinology, Jinan, Shandong, China.
  • Fufeng Liu
    Key Laboratory of Industrial Fermentation Microbiology, Ministry of Education, Tianjin Key Laboratory of Industrial Microbiology, College of Biotechnology, Tianjin University of Science and Technology, No.29 of 13th Street, TEDA, Tianjin 300457, PR China.
  • Chuanxi Zhang
    Department of Micro/Nano Electronics, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, No.800 Dongchuan Road, Minhang District, Shanghai 200240, China.
  • Yongfan Ming
    School of Automation, Central South University, Changsha, Hunan 410083, China.
  • Yulan Mou
    School of Chemistry and Molecular Engineering, East China Normal University, No.500 Dongchuan Road, Minhang District, Shanghai, China, Shanghai 200062, China.
  • ZhaoTing Yuan
    School of Chemistry and Molecular Engineering, East China Normal University, No.500 Dongchuan Road, Minhang District, Shanghai, China, Shanghai 200062, China.
  • Haiming Jiang
    School of Life Science and Technology, Inner Mongolia University of Science and Technology, No.7 Alding Street, Kundulun District, Baotou City, Inner Mongolia, Baotou 014010, China.
  • Bei Gao
    School of Biotechnology, East China University of Science and Technology, No.130 Meilong Road, Xuhui District, Shanghai 200237, China.
  • Fuping Lu
    School of Biotechnology, Tianjin University of Science and Technology, No.9, 13th Street, Economic and Technological Development Zone, Binhai New Area, Tianjin 300457, China.
  • Lujia Zhang
    School of Chemistry and Molecular Engineering, East China Normal University, No.500 Dongchuan Road, Minhang District, Shanghai, China, Shanghai 200062, China.

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