The Evolution of Artificial Intelligence in Nuclear Medicine.

Journal: Seminars in nuclear medicine
PMID:

Abstract

Nuclear medicine has continuously evolved since its beginnings, constantly improving the diagnosis and treatment of various diseases. The integration of artificial intelligence (AI) is one of the latest revolutionizing chapters, promising significant advancements in diagnosis, prognosis, segmentation, image quality enhancement, and theranostics. Early AI applications in nuclear medicine focused on improving diagnostic accuracy, leveraging machine learning algorithms for disease classification and outcome prediction. Advances in deep learning, including convolutional and more recently transformer-based neural networks, have further enabled more precise diagnosis and image segmentation as well as low-dose imaging, and patient-specific dosimetry for personalized treatment. Generative AI, driven by large language models and diffusion techniques, is now allowing the process, interpretation, and generation of complex medical language and images. Despite these achievements, challenges such as data scarcity, heterogeneity, and ethical concerns remain barriers to clinical translation. Addressing these issues through interdisciplinary collaboration will pave the way for a broader adoption of AI in nuclear medicine, potentially enhancing patient care and optimizing diagnosis and therapeutic outcomes.

Authors

  • Leonor Lopes
    Department of Nuclear Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland; Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland. Electronic address: leonor.serranolopes@unibe.ch.
  • Alejandro Lopez-Montes
    Department of Nuclear Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
  • Yizhou Chen
    School of Computer Science and Artificial Intelligence, Wuhan University of Technology, Wuhan 430070, China.
  • Pia Koller
    Department of Computer Science, Ludwig-Maximilians-University of Munich, Munich, Germany.
  • Narendra Rathod
    Department of Nuclear Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
  • August Blomgren
    Department of Nuclear Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland; Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland.
  • Federico Caobelli
    Department of Radiology and Nuclear Medicine, University Hospital, Basel and University of Basel, Petersgraben 4, 4031 Basel, Switzerland.
  • Axel Rominger
  • Kuangyu Shi
    Universitätsklinik für Nuklearmedizin, Inselspital University Hospital Bern, University of Bern, Bern, Switzerland.
  • Robert Seifert
    Department of Nuclear Medicine, Medical Faculty, University Hospital Essen, Essen, Deutschland.