Unlocking protein networks with Predictomes: The SPOC advantage.
Journal:
Molecular cell
PMID:
40118037
Abstract
In this issue of Molecular Cell, Schmid and Walter present "Predictomes," a machine-learning-based platform that utilizes AlphaFold-Multimer (AF-M) to identify high-confidence protein-protein interactions (PPIs). Their SPOC classifier is better than existing methods at separating true and false interactions.