AIMC Topic: Protein Interaction Maps
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MESM: integrating multi-source data for high-accuracy protein-protein interactions prediction through multimodal language models.
BMC biology
Aug 11, 2025
BACKGROUND: Protein-protein interactions (PPIs) play a critical role in essential biological processes such as signal transduction, enzyme activity regulation, cytoskeletal structure, immune responses, and gene regulation. However, current methods ma...
Identifying ferroptosis-related genes in lung adenocarcinoma using random walk with restart in the PPI network.
Scientific reports
Aug 6, 2025
Lung adenocarcinoma (LUAD), the most common non-small cell lung cancer subtype, often presents with subtle early symptoms leading to delayed diagnosis. Ferroptosis, a cell death process associated with iron metabolism dysregulation, has been linked t...
Identification and validation of ANXA3 and SOCS3 as biomarkers for acute myocardial infarction related to sphingolipid metabolism.
Hereditas
Aug 4, 2025
BACKGROUND: Sphingolipid metabolism (SM) is linked to acute myocardial infarction (AMI), but its role remains unclear. This study explored SM-related genes (SMRGs) in AMI to support clinical diagnosis.
Integrative network pharmacology and multi-omics reveal anisodamine hydrobromide's multi-target mechanisms in sepsis.
Scientific reports
Jul 31, 2025
Sepsis, marked by hyperinflammation and subsequent immunosuppression, lacks effective phase-specific therapies. Although anisodamine hydrobromide (Ani HBr) reduced 28-day mortality in our prior trial, its mechanisms remained unclear. Here, we integra...
Interpretable graph Kolmogorov-Arnold networks for multi-cancer classification and biomarker identification using multi-omics data.
Scientific reports
Jul 29, 2025
The integration of heterogeneous multi-omics datasets at a systems level remains a central challenge for developing analytical and computational models in precision cancer diagnostics. This paper introduces Multi-Omics Graph Kolmogorov-Arnold Network...
A deep ensemble framework for human essential gene prediction by integrating multi-omics data.
Scientific reports
Jul 21, 2025
Essential genes are necessary for the survival or reproduction of a living organism. The prediction and analysis of gene essentiality can advance our understanding of basic life and human diseases, and further boost the development of new drugs. We p...
Exploration of common pathogenic genes between cerebral amyloid angiopathy and insomnia based on bioinformatics and experimental validation.
Scientific reports
Jul 20, 2025
Cerebral amyloid angiopathy (CAA) and insomnia are age-related neurological disorders increasingly recognized as being closely associated. However, research on the shared genes and their biological mechanisms remains limited. This study aims to ident...
Prediction of hub genes in pulpal inflammation and regeneration using autoencoders and a generative AI approach.
Scientific reports
Jul 19, 2025
Pulpal inflammation and regeneration are crucial for enhancing endodontic treatment outcomes. Transcriptomic studies highlight the involvement of proinflammatory cytokines, NF-κB signaling, and stem cell activity. This study employs a generative AI a...
Shared pathogenic mechanisms linking obesity and idiopathic pulmonary fibrosis revealed by bioinformatics and in vivo validation.
Scientific reports
Jul 17, 2025
Previous studies have suggested a potential correlation between obesity and idiopathic pulmonary fibrosis (IPF). This study aimed to elucidate pathogenic pathways connecting obesity and IPF and identify diagnostic biomarkers for obesity-related pulmo...
Multi-tissue Methylation Analysis of Alzheimer's Disease: Insights into Pathways, Modules, and Key Genes.
Journal of molecular neuroscience : MN
Jul 16, 2025
DNA methylation plays a crucial role in the onset and progression of Alzheimer's disease (AD). Genome-wide methylation analysis of multi-tissue data can provide insights into the pathology and diagnostic biomarkers of AD. Computational tools were emp...
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