MCNEL: A multi-scale convolutional network and ensemble learning for Alzheimer's disease diagnosis.

Journal: Computer methods and programs in biomedicine
PMID:

Abstract

BACKGROUND AND OBJECTIVE: Alzheimer's disease (AD) significantly threatens community well-being and healthcare resource allocation due to its high incidence and mortality. Therefore, early detection and intervention are crucial for reducing AD-related fatalities. However, the existing deep learning-based approaches often struggle to capture complex structural features of magnetic resonance imaging (MRI) data effectively. Common techniques for multi-scale feature fusion, such as direct summation and concatenation methods, often introduce redundant noise that can negatively affect model performance. These challenges highlight the need for developing more advanced methods to improve feature extraction and fusion, aiming to enhance diagnostic accuracy.

Authors

  • Fei Yan
    Department of Infectious Diseases, Affiliated Taizhou Hospital of Wenzhou Medical University, No.50 Ximeng Road, Taizhou, 317000, China.
  • Lixing Peng
    School of Computer Science and Technology, Changchun University of Science and Technology, Changchun 130022, China.
  • Fangyan Dong
    Faculty of Mechanical Engineering & Mechanics, Ningbo University, Ningbo 315211, China. Electronic address: dongfangyan@nbu.edu.cn.
  • Kaoru Hirota