Integration of Photodiagnosis and Therapy Guided by Micro/Nanorobots.

Journal: Advanced materials (Deerfield Beach, Fla.)
PMID:

Abstract

Micro/Nanorobots(MNRs)integrated with phototherapy represent an emerging approach to cancer treatment and hold significant potential for addressing bacterial infections, neurological disorders, cardiovascular diseases, and related conditions. By leveraging micro/nanoscale motor systems in conjunction with phototherapy, these robots enable real-time guidance and monitoring of therapeutic processes, improving drug delivery precision and efficiency. This integration not only enhances the effectiveness of phototherapy but also minimizes damage to surrounding healthy tissues. Nevertheless, clinical translation of MNRs-assisted phototherapy still faces numerous challenges. In this review, recent key developments in the field are comprehensively summarized, the critical roles of MNRs-assisted phototherapy in clinical applications are highlighted, and insights into future directions and the pathway toward large-scale clinical implementation are provided.

Authors

  • Qihang Ding
    Engineering Research Center for Pharmaceuticals and Equipments of Sichuan Province, Sichuan Industrial Institute of Antibiotics, School of Pharmacy, Chengdu University, Chengdu, 610106, China.
  • Siqi Huang
    School of Software Engineering and College of Life Science & Technology, Huazhong University of Science and Technology, Wuhan 430074, China.
  • Zihan Zhang
  • Donghu Yu
    Brain Glioma Center & Department of Neurosurgery, International Science and Technology Cooperation Base for Research and Clinical techniques for Brain Glioma Diagnosis and Treatment, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China.
  • Man Li
    Department of Psychogeriatrics, Kangci Hospital of Jiaxing, Tongxiang, Zhejiang, China.
  • Qin He
    Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, Med-X Center for Materials, West China School of Pharmacy, Sichuan University, Chengdu, 610041, China. Electronic address: qinhe@scu.edu.cn.
  • Ling Mei
    Wuhan Hospital of Traditional Chinese Medicine, Wuhan, China.