Development of model for identifying homologous recombination deficiency (HRD) status of ovarian cancer with deep learning on whole slide images.

Journal: Journal of translational medicine
PMID:

Abstract

BACKGROUND: Homologous recombination deficiency (HRD) refers to the dysfunction of homologous recombination repair (HRR) at the cellular level. The assessment of HRD status has the important significance for the formulation of treatment plans, efficacy evaluation, and prognosis prediction of patients with ovarian cancer.

Authors

  • Ke Zhang
    Center for Radiation Oncology, Affiliated Hangzhou Cancer Hospital, Zhejiang University School of Medicine, Hangzhou 310001, China.
  • Youhui Qiu
    Department of Surgery, Changting Maternity and Children's Hospital, Longyan, Fujian, China.
  • Songwei Feng
    Department of Obstetrics and Gynaecology, School of Medicine, Zhongda Hospital, Southeast University, Nanjing, 210009, China.
  • Han Yin
    Department of Obstetrics and Gynaecology, School of Medicine, Zhongda Hospital, Southeast University, Nanjing, 210009, China.
  • Qi Liu
    National Institute of Traditional Chinese Medicine Constitution and Preventive Medicine, Beijing University of Chinese Medicine, Beijing, China.
  • Yuxin Zhu
    Division of Biostatistics and Bioinformatics, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Haoyu Cui
    Institute for AI in Medicine, School of Artificial Intelligence, Nanjing University of Information Science and Technology, Nanjing, China.
  • Xiaoying Wei
    Department of Tuberculosis, The Fourth People's Hospital of Nanning, Nanning, China.
  • Guoqing Wang
    Department of Pathogenobiology, Basic Medical College of Jilin University, Changchun, Jilin, 130012, People's Republic of China. qing@jlu.edu.cn.
  • Xiangxue Wang
    lnstitute for Al in Medicine, School of Artificial lntelligence, Nanjing University of Information Science and Technology, Nanjing, China.
  • Yang Shen
    Departments of Electrical and Computer Engineering & Computer Science and Engineering Texas A&M University, College Station, TX 77840.