Adoptive cell therapy (ACT) has demonstrated curative potential in select cancers, but its translation to solid tumors such as ovarian cancer (OC) has been hindered by multiple factors, including tumor heterogeneity, immune exclusion, and a profoundl...
Journal of the Egyptian National Cancer Institute
Jan 5, 2026
BACKGROUND: Ovarian cancer remains the most lethal gynecological malignancy, necessitating precise diagnostic strategies to improve patient outcomes. This study aims to develop and evaluate machine learning models that utilize patient history, imagin...
Precision oncology enables molecularly guided cancer therapy through multi-omics profiling, AI-driven classification, and biomarker-targeted interventions. Disulfidptosis has emerged as a promising therapeutic target, yet no ovarian cancer classifica...
Epithelial ovarian cancer (EOC) is a lethal gynecological malignancy. Ongoing research aimed to identify novel biomarkers and develop combined algorithms to improve diagnosis and prognosis prediction for EOC. RNA-seq related to EOC were obtained from...
BACKGROUND: Ovarian cancer (OC) demonstrates the poorest prognosis among gynecological malignancies, with five-year survival rates below 45%, primarily due to late-stage diagnosis. To address this challenge, we systematically identified OC-specific d...
Journal of the American Chemical Society
Oct 23, 2025
Aptamers are powerful synthetic recognition elements for biosensing, yet their application in complex biofluids, such as human serum, is critically limited by enzymatic degradation. To overcome this fundamental challenge, we introduce a novel analyti...
Malignant ovarian tumors (MOTs) and borderline ovarian tumors (BOTs) differ in treatment strategies and prognosis. However, accurate preoperative diagnosis remains challenging, and improving diagnostic accuracy is crucial. We developed and validated ...
Ovarian cancer (OVCA) is third most lethal gynecologic cancers and acquired chemoresistance is the key link in the high mortality rate of OVCA patients. Currently, there are no reliable methods to predict chemoresistance in OVCA. In our study, we ide...
Dual-omics, by integrating molecular information from two distinct dimensions, can offer more comprehensive perspective for complex disease. Herein, we developed an efficient functionalized mesoporous nanoparticle-coupled laser desorption/ionization ...
BACKGROUND: Ovarian cancer (OC) poses a significant public health challenge due to its dismal prognosis and low survival rates. However, the mechanism of OC development remains unclear.
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