Identification of cancerous tissues based on residual neural network.

Journal: Scientific reports
PMID:

Abstract

The identification of cancerous tissues remains challenging due to the complexity of experimental methods and low identification accuracy rates. Therefore, this paper proposes a rapid identification method. We introduce a new theoretical transmission method for modeling laser beams transport in cancerous and normal biological tissues. Using this method, laser speckle patterns carrying tissue information are obtained at the light transmission receiving plane. Then, we propose a three-task residual neural network, T-ResNet-18, for identifying speckle images. We simulate the human normal and cancerous prostate tissues, rat normal and cancerous tissues, and normal and abnormal cell suspension as training samples. The results show the identification accuracy exceeding 99%. Additionally, we discuss the impact of varying dataset sizes, training epochs, and tissue thickness on identification accuracy and compare the performance of T-ResNet-18 with ResNet-18, VGG16 and AlexNet, showing that T-ResNet-18 significantly outperforms classic neural networks.

Authors

  • Ying Liu
    The First School of Clinical Medicine, Lanzhou University, Lanzhou, China.
  • Xiaoyun Liu
    Department of General Medicine, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
  • Siyu Gao
    The Key Laboratory for Biomedical Photonics of MOE at Wuhan National Laboratory for Optoelectronics-Hubei Bioinformatics & Molecular Imaging Key Laboratory, Systems Biology Theme, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China.
  • Tengfei Chai
    School of Science, Shenyang Ligong University, Shenyang, 110159, China.
  • Zihao Zhao
    School of Information and Computer, Anhui Agricultural University, Hefei 230036, China.
  • Hongwei Wang
    Department of Oncological Surgery, Harbin Medical University Cancer Hospital, Harbin, 150000, Heilongjiang Province, China.
  • Yumeihui Jin
    School of Science, Shenyang Ligong University, Shenyang, 110159, China.
  • Yueqiu Jiang
    College of information science and engineering, Shenyang Ligong University, No.6, nanping middle road, hunnan new district, Shenyang, Liaoning, 110159, China.