Fetal origins of adult disease: transforming prenatal care by integrating Barker's Hypothesis with AI-driven 4D ultrasound.

Journal: Journal of perinatal medicine
PMID: 40195943

Abstract

INTRODUCTION: The fetal origins of adult disease, widely known as Barker's Hypothesis, suggest that adverse fetal environments significantly impact the risk of developing chronic diseases, such as diabetes and cardiovascular conditions, in adulthood. Recent advancements in 4D ultrasound (4D US) and artificial intelligence (AI) technologies offer a promising avenue for improving prenatal diagnostics and validating this hypothesis. These innovations provide detailed insights into fetal behavior and neurodevelopment, linking early developmental markers to long-term health outcomes.

Authors

  • Wiku Andonotopo
    Fetomaternal Division, Department of Obstetrics and Gynecology, Ekahospital BSD City, Serpong, Tangerang, Banten, Indonesia.
  • Muhammad Adrianes Bachnas
    Fetomaternal Division, Department of Obstetrics and Gynecology, Medical Faculty of Sebelas Maret University, Moewardi Hospital, Solo, Surakarta, Indonesia.
  • Muhammad Ilham Aldika Akbar
    Department of Obstetrics and Gynecology, Universitas Airlangga Hospital - Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.
  • Muhammad Alamsyah Aziz
    Department of Obstetrics and Gynecology, Faculty of Medicine, Maternal-Fetal Medicine Division, Padjadjaran University, Hasan Sadikin General Hospital, Bandung, Indonesia.
  • Julian Dewantiningrum
    Fetomaternal Division, Department of Obstetrics and Gynecology, Medical Faculty of Diponegoro University, Dr. Kariadi Hospital, Semarang, Indonesia.
  • Mochammad Besari Adi Pramono
    Department of Obstetrics and Gynecology, Faculty of Medicine, Maternal-Fetal Medicine Division, Diponegoro University, Dr. Kariadi General Hospital, Semarang, Indonesia.
  • Sri Sulistyowati
    Department of Obstetrics and Gynecology, Faculty of Medicine, Maternal-Fetal Medicine Division, Sebelas Maret University, Sebelas Maret University Hospital, Solo, Indonesia.
  • Milan Stanojevic
    Department of Obstetrics and Gynecology, University Hospital "Sveti Duh", Zagreb, Croatia.
  • Asim Kurjak
    Department of Obstetrics and Gynecology, Medical School University of Zagreb, Zagreb, Croatia.

Keywords

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