Determinants of ascending aortic morphology: cross-sectional deep learning-based analysis on 25 073 non-contrast-enhanced NAKO MRI studies.

Journal: European heart journal. Cardiovascular Imaging
PMID:

Abstract

AIMS: Understanding determinants of thoracic aortic morphology is crucial for precise diagnostics and therapeutic approaches. This study aimed to automatically characterize ascending aortic morphology based on 3D non-contrast-enhanced magnetic resonance angiography (NC-MRA) data from the epidemiological cross-sectional German National Cohort (NAKO) and to investigate possible determinants of mid-ascending aortic diameter (mid-AAoD).

Authors

  • Louisa Fay
    Department for Diagnostic and Interventional Radiology, University Hospital Tuebingen, Hoppe-Seyler-Straße 3, 72076 Tuebingen, Germany.
  • Tobias Hepp
    University of Tübingen, Department of Radiology, Tübingen, Germany.
  • Moritz T Winkelmann
    Department of Radiology, Diagnostic and Interventional Radiology, University of Tübingen, 72076, Tübingen, Germany.
  • Annette Peters
    Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
  • Margit Heier
    Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich-Neuherberg, Germany.
  • Thoralf Niendorf
    Berlin Ultrahigh Field Facility, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.
  • Tobias Pischon
    Max-Delbrueck-Center for Molecular Medicine in the Helmholtz Association (MDC), Molecular Epidemiology Research Group, Berlin, Germany.
  • Beate Endemann
    Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.
  • Jeanette Schulz-Menger
    Charité-Universitätsmedizin Berlin, Experimental and Clinical Research Center, Working Group On CMR and HELIOS Klinikum Berlin Buch, Cardiology Berlin, DZHK partnersite Berlin, Berlin, Germany.
  • Lilian Krist
    Institute of Social Medicine, Epidemiology and Health Economics of the Charité, Berlin, Germany.
  • Matthias B Schulze
    Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.
  • Rafael Mikolajczyk
    Institute for Medical Epidemiology, Biometrics and Informatics, Interdisciplinary Center for Health Sciences, Faculty of Medicine, Martin-Luther-University Halle-Wittenberg, Halle, Germany.
  • Andreas Wienke
    Institute of Medical Epidemiology, Biometry, and Informatics, Profile Center Health Sciences, Faculty of Medicine, Martin-Luther-University Halle-Wittenberg, Halle, Germany.
  • Nadia Obi
    Institute for Occupational and Maritime Medicine (ZfAM), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.
  • Bernard C Silenou
    Department of Epidemiology, Helmholtz-Centre for Infection Research, Braunschweig, Germany.
  • Berit Lange
    Department of Epidemiology, Helmholtz-Centre for Infection Research, Braunschweig, Germany.
  • Hans-Ulrich Kauczor
    Department of Diagnostic and Interventional Radiology, Heidelberg University Hospital, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany.
  • Wolfgang Lieb
    Institute of Epidemiology, Christian-Albrechts-University of Kiel, Kiel, Germany.
  • Hansjörg Baurecht
    Department of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany.
  • Michael Leitzmann
    Department of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany.
  • Kira Trares
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Hermann Brenner
    German Cancer Consortium (DKTK), Heidelberg, Germany.
  • Karin B Michels
    Institute for Prevention and Cancer Epidemiology, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany.
  • Stefanie Jaskulski
    Institute for Prevention and Cancer Epidemiology, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany.
  • Henry Völzke
    Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
  • Konstantin Nikolaou
    Department of Diagnostic and Interventional Radiology, Eberhard-Karls-University, Hoppe-Seyler-Str.3, 72076 Tübingen, Germany.
  • Christopher L Schlett
    From the MTA-SE Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University, 68 Varosmajor St, 1122 Budapest, Hungary (M.K., J.K., B.M., P.M.H.); Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Mass (J.K., Y.K., A.I., M.T.L., B.F., H.J.A., U.H.); Center for Cause of Death Investigation, Faculty of Medicine, Hokkaido University, Hokkaido, Japan (Y.K.); Department for Diagnostic and Interventional Radiology, Medical Center-University of Freiburg, Freiburg, Germany (C.L.S.); and Department of Radiation Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass (H.J.A.).
  • Fabian Bamberg
    Department of Diagnostic and Interventional Radiology, University Medical Center Tübingen, Tübingen, Germany.
  • Mario Lescan
    Clinic for Cardiovascular Surgery, Department University Heart Center Freiburg Bad Krozingen, University Clinic Freiburg, Freiburg, Germany.
  • Bin Yang
    School of Control Science and Engineering, Dalian University of Technology, Dalian 116024, PR China. Electronic address: yangbin@dlut.edu.cn.
  • Thomas Küstner
    Department of Radiology, Diagnostic and Interventional Radiology, Eberhard Karls University Tübingen, Germany.
  • Sergios Gatidis
    Department of Radiology, Diagnostic and Interventional Radiology, Eberhard Karls University Tübingen, Germany.