Identifying Lactylation-related biomarkers and therapeutic drugs in ulcerative colitis: insights from machine learning and molecular docking.

Journal: BMC pharmacology & toxicology
PMID: 40361222

Abstract

BACKGROUND: Ulcerative colitis (UC), a chronic relapsing-remitting inflammatory bowel disease. Recent studies have shown that lactylation modifications may be involved in metabolic-immune interactions in intestinal inflammation through epigenetic regulation, but their specific mechanisms in UC still require in-depth validation.

Authors

  • Yao Yang
    Surgrey of Pediatric Heart Center, Beijing Anzhen Hospital Affiliated to Capital Medical University, Beijing 100029, P.R.China.
  • Xu Sun
    MOE Key Laboratory of Computational Linguistics, School of EECS, Peking University, Beijing, China; Center for Data Science, Peking University, Beijing, China. Electronic address: xusun@pku.edu.cn.
  • Bin Liu
    Department of Endocrinology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China; Department of Endocrinology, Neijiang First People's Hospital, Chongqing, China.
  • Yunshu Zhang
    Department of Statistics, North Carolina State University, Raleigh, NC, USA.
  • Tong Xie
    Department of Food Science and Technology, Shanghai Institute of Technology, Shanghai 201418, China.
  • Junchen Li
    Department of Radiology, Changshu Hospital Affiliated to Nanjing University of Chinese Medicine, China.
  • Jifeng Liu
    Department of General Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China. jifeng0213@163.com.
  • Qingkai Zhang
    Department of General Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China. dlkaiyu@163.com.

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