BACKGROUND: Our research team previously found that fibroblast growth factor (FGF) 21, a circulating hormone, was significantly associated with atherosclerosis in human and animal models. The relationship between FGF21 and blood pressure (BP) is rare...
BACKGROUND: Ulcerative colitis (UC), a chronic relapsing-remitting inflammatory bowel disease. Recent studies have shown that lactylation modifications may be involved in metabolic-immune interactions in intestinal inflammation through epigenetic reg...
BACKGROUND: Metabolic associated steatohepatitis (MASH) represents a severe subtype of metabolic associated fatty liver disease (MASLD), with an increased risk of progression to cirrhosis and hepatocellular carcinoma. The nomenclature shift from nona...
Depression presents a significant challenge to global mental health, often intertwined with factors including oxidative stress. Although the precise relationship with mitochondrial pathways remains elusive, recent advances in machine learning present...
BACKGROUND: Individuals with diabetic kidney disease (DKD) often suffer cardiac and kidney events. We sought to develop an accurate means by which to stratify risk in DKD.
BACKGROUND: Cardiotoxicity is a major concern in heart disease research because it can lead to severe cardiac damage, including heart failure and arrhythmias.
Understanding the molecular underpinnings of CAD is essential for developing effective therapeutic strategies. This study aims to identify and analyze differentially expressed hub biomarkers in the peripheral blood of CAD patients. Based on RNA-seq d...
To study the differences in the urine metabolome between pediatric patients with severe Mycoplasma pneumoniae pneumonia (SMPP) and those with general Mycoplasma pneumoniae pneumonia (GMPP) via non-targeted metabolomics method, and potential biomarker...
Dementia spectrum disorders, characterized by progressive cognitive decline, pose a significant global health burden. Early screening and diagnosis are essential for timely and accurate treatment, improving patient outcomes and quality of life. This ...
BACKGROUND: Infection by the SARS-CoV-2 virus can cause coronavirus disease 2019 (COVID-19) and can also exacerbate the symptoms of Kawasaki disease (KD), an acute vasculitis that mostly affects children. This study used bioinformatics and machine le...