Integrated network toxicology, machine learning and molecular docking reveal the mechanism of benzopyrene-induced periodontitis.

Journal: BMC pharmacology & toxicology
Published Date: Jun 6, 2025

Abstract

BACKGROUND: Environmental pollutants, particularly from air pollution and tobacco smoke, have emerged as significant risk factors. Benzopyrene (BaP), a Group 1 carcinogen, is ubiquitously present in these pollutants, yet its molecular mechanisms in periodontitis remain largely unexplored.

Authors

  • Wen Wenjie
    Anhui Province Engineering Research Center for Dental Materials and Application, School of Stomatology, Wannan Medical College, Wuhu, 241002, China.
  • Li Rui
    Anhui Province Engineering Research Center for Dental Materials and Application, School of Stomatology, Wannan Medical College, Wuhu, 241002, China.
  • Zhuo Pengpeng
    Anhui Province Engineering Research Center for Dental Materials and Application, School of Stomatology, Wannan Medical College, Wuhu, 241002, China.
  • Deng Chao
    Anhui Province Engineering Research Center for Dental Materials and Application, School of Stomatology, Wannan Medical College, Wuhu, 241002, China. 20120015@wnmc.edu.cn.
  • Zhang Donglin
    Anhui Province Engineering Research Center for Dental Materials and Application, School of Stomatology, Wannan Medical College, Wuhu, 241002, China. 19900005@wnmc.edu.cn.

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