MORPSO_ECD+ELM: A Unified Framework for Gene Selection and Cancer Classification.
Journal:
IEEE journal of biomedical and health informatics
Published Date:
Jun 1, 2025
Abstract
Gene selection and cancer classification are inherently multi-objective tasks that require balancing competing objectives, such as maximizing classification accuracy while minimizing irrelevant or redundant genes. Existing methods often optimize a single objective or treat gene selection and classification independently, limiting their overall effectiveness. This study proposes a unified framework, MORPSO_ECD+ELM, which formulates gene selection and classification as a multimodal multi-objective optimization problem (MMOP) to optimize both objectives simultaneously. The framework introduces two key innovations: (1) an enhanced crowding distance (ECD) metric to improve diversity preservation and (2) an advanced multi-objective particle swarm optimization variant (MORPSO_ECD) that incorporates ECD and ring topography to effectively explore the MMOP solution space. Integrated with the Extreme Learning Machine (ELM), this framework achieves robust and efficient cancer classification. Extensive experimental validations demonstrate that the proposed approach achieves high classification accuracy while identifying biologically meaningful gene subsets, providing a powerful solution to bridge the gap between gene selection and cancer classification.
