KDELR3 and YOD1 proteins as critical endoplasmic reticulum stress mediators and potential therapeutic targets in diabetic foot ulcers: An integrated bioinformatics analysis.

Journal: International journal of biological macromolecules
Published Date:

Abstract

BACKGROUND: Diabetic foot ulcers (DFU) represent one of the most severe complications of diabetes mellitus and are closely associated with persistent hyperglycemia. Endoplasmic reticulum stress response proteins play critical roles in the development and progression of DFU, highlighting the urgent need for further research to identify novel biomarkers and therapeutic strategies.

Authors

  • Rongbin Zhou
    Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co-Constructed By the Province and Ministry, Guangxi Medical University, No. 22, Shuangyong Road, Qingxiu District, Nanning City, 530021, Guangxi Zhuang Autonomous Region, People's Republic of China.
  • Xiaochong Zou
    Department of Urology, the First Affiliated Hospital of Guangxi Medical University, Guangxi Medical University, Guangxi 530021, China.
  • Jiayin Yu
    Department of Hepatobiliary and Pancreatic Surgery, First Hospital of Jiaxing, Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang, China.
  • Zuheng Wang
    Department of Urology, Jinling Hospital, Medical School of Nanjing University, Nanjing, 210002, China.
  • Wenhao Lu
    School of Electrical and Electronic Engineering, Nanyang Technological University, Nanyang Avenue, 639798, Singapore.
  • Xiao Li
    Department of Inner Mongolia Clinical Medicine College, Inner Mongolia Medical University, Hohhot, Inner Mongolia, China.
  • Chunmeng Wei
    Center for Genomic and Personalized Medicine, Guangxi Key Laboratory for Genomic and Personalized Medicine, Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, 530021, Guangxi, China.
  • Xing Li
    Department of Nutrition and food hygiene, College of Public Health of Zhengzhou University, Zhengzhou, China, 450001. Electronic address: 526924683@qq.com.
  • Fubo Wang
    Center for Genomic and Personalized Medicine, Guangxi Key Laboratory for Genomic and Personalized Medicine, Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, 530021, Guangxi, China. wangbofengye@163.com.