TMEM132A: a novel susceptibility gene for lung adenocarcinoma combined with venous thromboembolism identified through comprehensive bioinformatic analysis.

Pulmonology Transplantation Genetics Public Health & Policy State Required CME
Journal: Frontiers in oncology
Published Date: Jan 1, 2025

Abstract

BACKGROUND: Mounting evidence indicates that lung adenocarcinoma (LUAD) patients are at elevated risk for venous thromboembolism (VTE), presenting a major clinical challenge. This study utilized public databases to identify crosstalk genes (CGs) between LUAD and VTE, applied machine learning methods to discover shared diagnostic biomarkers, and explored their underlying mechanisms.

Authors

  • Pei Xie
    Department of Pulmonary and Critical Care Medicine, Zhengzhou University People's Hospital, Henan Provincial People's Hospital CN, Zhengzhou, China.
  • Yingli Liu
    Department of Pulmonary and Critical Care Medicine, Zhengzhou University People's Hospital, Henan Provincial People's Hospital CN, Zhengzhou, China.
  • Pingping Bai
    Department of Pulmonary and Critical Care Medicine, Zhengzhou University People's Hospital, Henan Provincial People's Hospital CN, Zhengzhou, China.
  • Yue Ming
    Beijing Key Laboratory of Work Safety and Intelligent Monitoring, School of Electronic Engineering, Beijing University of Posts and Telecommunications, Beijing, China.
  • Qi Zheng
    School of Labor Economics, Capital University of Economics and Business, Beijing, China.
  • Li Zhu
    Medical College, Yangzhou University, Yangzhou 225001, China.
  • Yong Qi
    School of Computer Science and Engineering, Nanjing University of Science and Technology, Nanjing 210094, China.

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