ASOptimizer: optimizing chemical diversity of antisense oligonucleotides through deep learning.
Journal:
Nucleic acids research
Published Date:
Jul 7, 2025
Abstract
Antisense oligonucleotides (ASOs) are a promising class of gene therapies that can modulate the gene expression. However, designing ASOs manually is resource-intensive and time-consuming. To address this, we introduce a user-friendly web server for ASOptimizer, a deep learning-based computational framework for optimizing ASO sequences and chemical modifications. Given a user-provided ASO sequence, the web server systematically explores modification sites within the nucleic acid and returns a ranked list of promising modification patterns. With an intuitive interface requiring no expertise in deep learning tools, the platform makes ASOptimizer easily accessible to the broader research community. The web server is freely available at https://asoptimizer.s-core.ai/.
