IL-27 as a novel biomarker for pruritus in nodular prurigo and bullous pemphigoid.

Journal: Frontiers in immunology
PMID: 39735535

Abstract

INTRODUCTION: Bullous pemphigoid (BP) and prurigo nodularis (PN) are chronic pruritic skin diseases that severely impact patients' quality of life. Despite the widespread attention these two diseases have garnered within the dermatological field, the specific pathogenesis, particularly the molecular mechanisms underlying the pruritus, remains largely unclear. Limited clinical sequencing studies focusing on BP and PN have hindered the identification of pathological mechanisms and the exploration of effective treatment strategies.

Authors

  • Yifei Wang
    Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Xin Zhang
    First Department of Infectious Diseases, The First Affiliated Hospital of China Medical University, Shenyang, China.
  • Yun Te Teng
    Department of Dermatology, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, China.
  • Chen Shen
    Department of Foreign Languages, Xi'an Jiaotong University City College, Xi'an, China.

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