PREACT-digital: study protocol for a longitudinal, observational multicentre study on digital phenotypes of non-response to cognitive behavioural therapy for internalising disorders.

Journal: BMJ open
Published Date:

Abstract

INTRODUCTION: Cognitive behavioural therapy (CBT) serves as a first-line treatment for internalising disorders (ID), encompassing depressive, anxiety or obsessive-compulsive disorders. Nonetheless, a substantial proportion of patients do not experience sufficient symptom relief. Recent advances in wearable technology and smartphone integration enable new, ecologically valid approaches to capture dynamic processes in real time. By combining ecological momentary assessment (EMA) with passive sensing of behavioural and physiological information, this project seeks to track daily fluctuations in symptom-associated constructs like affect, emotion regulation (ER) and physical activity. Our central goal is to determine whether dynamic, multimodal markers derived from EMA and passive sensing can predict treatment non-response and illuminate key factors that drive or hinder therapeutic change.

Authors

  • Leona Hammelrath
    Department of Education and Psychology, Freie Universität Berlin, Berlin, Germany.
  • Annette Brose
    Department of Clinical Psychological Intervention, Freie Universität Berlin, Berlin, Germany.
  • Manuel Heinrich
    Department of Education and Psychology, Freie Universität Berlin, Berlin, Germany.
  • Pavle Zagorscak
    Department of Education and Psychology, Freie Universität Berlin, Berlin, Germany.
  • Sebastian Burchert
    Clinical-Psychological Intervention, Freie Universität Berlin Fachbereich Erziehungswissenschaft und Psychologie, Berlin, Germany.
  • Till Langhammer
    Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany.
  • Christine Knaevelsrud
    Department of Education and Psychology, Freie Universität Berlin, Berlin, Germany.