Recent advances of muconic acid production using microbial synthetic biology.

Journal: Archives of microbiology
Published Date: Aug 11, 2025

Abstract

Muconic acid is a high-value intermediate with unique properties. Traditional methods for muconic acid production showed some disadvantages including expensive raw materials, environmentally sensitive, and high concentration of heavy metal catalysts. With the development of synthetic biology, bio-strategies for muconic acid production have been widely studied. In this paper, key advances in muconic acid production using synthetic biology are highlighted. Furthermore, strategies for improving muconic acid production have been discussed, including cofactor engineering, modular co-culture, and artificial intelligence-assisted enzyme optimization. Given the significant advantages of biosynthesis in clean production and cost control, the paper concludes with an analysis of the economic and technical feasibility of microbial muconic acid production.

Authors

  • Xiqiang Liu
    Key Laboratory of Fermentation Engineering (Ministry of Education), Cooperative Innovation Center of Industrial Fermentation (Ministry of Education and Hubei Province), National "111" Center for Cellular Regulation and Molecular Pharmaceutics, Hubei University of Technology, Wuhan, 430068, People's Republic of China.
  • Jintao Lu
    Key Laboratory of Fermentation Engineering (Ministry of Education), Cooperative Innovation Center of Industrial Fermentation (Ministry of Education and Hubei Province), National "111" Center for Cellular Regulation and Molecular Pharmaceutics, Hubei University of Technology, Wuhan, 430068, People's Republic of China.
  • Siqi Chen
    College of Animal Science and Technology, Jilin Agricultural University, Changchun, China.
  • Mingyang Wang
    Department of Ultrasound, Tianjin First Central Hospital, NanKai University, Tianjin, 300192, China.
  • Aamer Ali Shah
    Department of Microbiology, Faculty of Biological Sciences, Quaid-i-Azam University, lslamabad, 45320, Pakistan.
  • Chunjie Gong
    Key Laboratory of Fermentation Engineering (Ministry of Education), Cooperative Innovation Center of Industrial Fermentation (Ministry of Education and Hubei Province), National "111" Center for Cellular Regulation and Molecular Pharmaceutics, Hubei University of Technology, Wuhan, 430068, People's Republic of China. gongcj606@163.com.

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