AIMC Topic: Metabolic Engineering

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Recent advances of muconic acid production using microbial synthetic biology.

Archives of microbiology Aug 11, 2025
Muconic acid is a high-value intermediate with unique properties. Traditional methods for muconic acid production showed some disadvantages including expensive raw materials, environmentally sensitive, and high concentration of heavy metal catalysts....
Sorbic Acid Metabolic Engineering Bacteria Synthetic Biology
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Computational Strategies to Enhance Vitamin B Biosynthesis Potential of Microbes.

Current microbiology Jul 4, 2025
Vitamin B is a vital nutrient for the normal functioning of many metabolic processes. It has a characteristic corrinoid ring structure with a cobalt ion. Its complex chemical structure demands 30 enzyme-catalyzed steps for synthesis. Deficiency of th...
Biosynthetic Pathways Metabolic Engineering Vitamin B 12 Synthetic Biology Bacteria Molecular Docking Simulation Computational Biology Genomics
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Regulation and induction of fungal secondary metabolites: a comprehensive review.

Archives of microbiology Jul 1, 2025
Fungal secondary metabolites (SMs) represent a vast reservoir of bioactive compounds with immense therapeutic, agricultural, and industrial potential. These small molecules, including antibiotics, immunosuppressants, and anticancer agents, are synthe...
Fungi Multigene Family Secondary Metabolism Metabolic Engineering Gene Expression Regulation, Fungal Biosynthetic Pathways
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Enabling malic acid production from corn-stover hydrolysate in Lipomyces starkeyi via metabolic engineering and bioprocess optimization.

Microbial cell factories May 21, 2025
BACKGROUND: Lipomyces starkeyi is an oleaginous yeast with a native metabolism well-suited for production of lipids and biofuels from complex lignocellulosic and waste feedstocks. Recent advances in genetic engineering tools have facilitated the deve...
Pyruvate Carboxylase Metabolic Engineering Malates Lipomyces Malate Dehydrogenase Fermentation Zea mays Bioreactors Aspergillus oryzae Hydrolysis
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Multiplexed engineering of cytochrome P450 enzymes for promoting terpenoid synthesis in Saccharomyces cerevisiae cell factories: A review.

Biotechnology advances Mar 9, 2025
Terpenoids, also known as isoprenoids, represent the largest and most structurally diverse family of natural products, and their biosynthesis is closely related to cytochrome P450 enzymes (P450s). Given the limitations of direct extraction from natur...
Saccharomyces cerevisiae Terpenes Cytochrome P-450 Enzyme System Protein Engineering Metabolic Engineering
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Metabolic reprogramming and machine learning-guided cofactor engineering to boost nicotinamide mononucleotide production in Escherichia coli.

Bioresource technology Mar 5, 2025
Nicotinamide mononucleotide (NMN) is a bioactive compound in NAD(P) metabolism, which exhibits diverse pharmaceutical interests. However, enhancing NMN biosynthesis faces the challange of competing with cell growth and disturbing intracellular redox ...
Machine Learning Escherichia coli Metabolic Engineering NADP Nicotinamide Mononucleotide Metabolic Reprogramming Fermentation Oxidation-Reduction Quorum Sensing
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AI-based automated construction of high-precision Geobacillus thermoglucosidasius enzyme constraint model.

Metabolic engineering Oct 18, 2024
Geobacillus thermoglucosidasius NCIMB 11955 possesses advantages, such as high-temperature tolerance, rapid growth rate, and low contamination risk. Additionally, it features efficient gene editing tools, making it one of the most promising next-gene...
Models, Biological Geobacillus Artificial Intelligence Bacillaceae Bacterial Proteins Metabolic Engineering
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Cell factory design with advanced metabolic modelling empowered by artificial intelligence.

Metabolic engineering Jul 20, 2024
Advances in synthetic biology and artificial intelligence (AI) have provided new opportunities for modern biotechnology. High-performance cell factories, the backbone of industrial biotechnology, are ultimately responsible for determining whether a b...
Synthetic Biology Metabolic Engineering Artificial Intelligence Models, Biological
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Machine learning for the advancement of genome-scale metabolic modeling.

Biotechnology advances Jun 27, 2024
Constraint-based modeling (CBM) has evolved as the core systems biology tool to map the interrelations between genotype, phenotype, and external environment. The recent advancement of high-throughput experimental approaches and multi-omics strategies...
Models, Biological Synthetic Biology Genome Metabolic Engineering Genomics Humans Systems Biology Machine Learning
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Advancing microbial production through artificial intelligence-aided biology.

Biotechnology advances Jun 24, 2024
Microbial cell factories (MCFs) have been leveraged to construct sustainable platforms for value-added compound production. To optimize metabolism and reach optimal productivity, synthetic biology has developed various genetic devices to engineer mic...
Protein Engineering Metabolic Engineering Artificial Intelligence Synthetic Biology
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