AIMC Topic: Synthetic Biology
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Recent advances of muconic acid production using microbial synthetic biology.
Archives of microbiology
Aug 11, 2025
Muconic acid is a high-value intermediate with unique properties. Traditional methods for muconic acid production showed some disadvantages including expensive raw materials, environmentally sensitive, and high concentration of heavy metal catalysts....
Data-driven synthetic microbes for sustainable future.
NPJ systems biology and applications
Jul 7, 2025
The escalating global environmental crisis demands transformative biotechnological solutions that are both sustainable and scalable. This perspective advocates Data-Driven Synthetic Microbes (DDSM); engineered microorganisms designed through integrat...
Computational Strategies to Enhance Vitamin B Biosynthesis Potential of Microbes.
Current microbiology
Jul 4, 2025
Vitamin B is a vital nutrient for the normal functioning of many metabolic processes. It has a characteristic corrinoid ring structure with a cobalt ion. Its complex chemical structure demands 30 enzyme-catalyzed steps for synthesis. Deficiency of th...
Abstraction hierarchy to define biofoundry workflows and operations for interoperable synthetic biology research and applications.
Nature communications
Jul 1, 2025
Lack of standardization in biofoundries limits the scalability and efficiency of synthetic biology research. Here, we propose an abstraction hierarchy that organizes biofoundry activities into four interoperable levels: Project, Service/Capability, W...
Optimizing phage therapy with artificial intelligence: a perspective.
Frontiers in cellular and infection microbiology
May 27, 2025
Phage therapy is emerging as a promising strategy against the growing threat of antimicrobial resistance, yet phage and bacteria are incredibly diverse and idiosyncratic in their interactions with one another. Clinical applications of phage therapy o...
Machine learning-led semi-automated medium optimization reveals salt as key for flaviolin production in Pseudomonas putida.
Communications biology
Apr 18, 2025
Although synthetic biology can produce valuable chemicals in a renewable manner, its progress is still hindered by a lack of predictive capabilities. Media optimization is a critical, and often overlooked, process which is essential to obtain the tit...
Scaling Up Synthetic Cell Production Using Robotics and Machine Learning Toward Therapeutic Applications.
Advanced biology
Mar 31, 2025
Synthetic cells (SCs), developed through bottom-up synthetic biology, hold great potential for biomedical applications, with the promise of replacing malfunctioning natural cells and treating diseases with spatiotemporal control. Currently, most SC s...
Combining diffusion and transformer models for enhanced promoter synthesis and strength prediction in deep learning.
mSystems
Mar 19, 2025
UNLABELLED: In the field of synthetic biology, the engineering of synthetic promoters that outperform their natural counterparts is of paramount importance, which can optimize the expression of exogenous genes, enhance the efficiency of metabolic pat...
A novel interpretability framework for enzyme turnover number prediction boosted by pre-trained enzyme embeddings and adaptive gate network.
Methods (San Diego, Calif.)
Feb 26, 2025
It is a vital step to identify the enzyme turnover number (kcat) in synthetic biology and early-stage drug discovery. Recently, deep learning methods have achieved inspiring process to predict kcat with the development of multi-species enzyme-substra...
Engineering a New Generation of Gene Editors: Integrating Synthetic Biology and AI Innovations.
ACS synthetic biology
Feb 25, 2025
CRISPR-Cas technology has revolutionized biology by enabling precise DNA and RNA edits with ease. However, significant challenges remain for translating this technology into clinical applications. Traditional protein engineering methods, such as rati...
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