AIMC Topic: Synthetic Biology

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Leveraging AI for cell biology discovery.

Biochemical Society transactions
Artificial intelligence (AI) has become a transformative tool in cell biology, driving discoveries through the analysis of complex biological data. This review explores the diverse applications of AI, including its impact on microscopy, imaging, drug...

A Framework for a Standard-Enabled FAIR Data Management Workflow for Synthetic Biology.

ACS synthetic biology
Synthetic biology laboratories generate diverse forms of data and metadata throughout a project's life cycle, such as sequences, models, protocols, images, and time-series measurements. Unfortunately, these assets are scattered across spreadsheets, p...

Dynamic Interaction: Synthetic Biology and Cell-Free Biosensors Drive Each Other Forward.

ACS nano
The convergence of synthetic biology and biosensor technology is driving a scientific and technological revolution in biotechnology. Characterized by its interdisciplinary nature, synthetic biology applies engineering principles to design and constru...

An LLM-Based Tool for Automated Generation of 3D Model Organism Colony Simulations.

ACS synthetic biology
We present MicroVerse, a software application based on large language models (LLMs) designed to generate C# scripts simulating three-dimensional colonies of model organisms, including and , within the Unity platform. The system, which utilizes fine-...

From Nano to Quantum: Ethics Through a Lens of Continuity.

Science and engineering ethics
A significant amount of scholarship and funding has been dedicated to ethical and social studies of new and emerging science and technology (NEST), from nanotechnology to synthetic biology, and Artificial Intelligence. Quantum technologies comprise t...

Monoclonal antibodies production in microbial systems: Current status, challenges and perspectives.

New biotechnology
Monoclonal antibodies (mAbs) serve as indispensable tools in diagnostics, clinical therapeutics, and biomedical research. However, their large-scale production faces significant challenges due to the high costs and lengthy timelines associated with c...

Rubisco-Centric Strategies for Carbon Conservation in Synthetic Biology.

Journal of agricultural and food chemistry
The escalating global climate crisis urgently demands biomanufacturing technologies with higher carbon efficiency. Ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco), the central enzyme catalyzing carbon dioxide fixation in the Calvin-Benson c...

AI-directed gene fusing prolongs the evolutionary half-life of synthetic gene circuits.

Science advances
Evolutionary instability is a persistent challenge in synthetic biology, often leading to the loss of heterologous gene expression over time. Here, we present STABLES, a gene fusion strategy that links a gene of interest (GOI) to an essential endogen...

Programmable Biointerfaces and Adaptive Functionality in Next-Generation Green Nanomaterials.

ACS synthetic biology
Recent advances in green nanomaterials have primarily focused on mitigating toxicity through passive approaches, yet emerging technologies suggest a transformative paradigm shift toward programmable nanomaterials with dynamic biointerfaces. This Revi...

Neural CRNs: A Natural Implementation of Learning in Chemical Reaction Networks.

ACS synthetic biology
Molecular circuits capable of autonomous learning could unlock novel applications in fields such as bioengineering and synthetic biology. To this end, existing chemical implementations of neural computing have primarily relied on emulating discrete-l...