Joint Toxicity of Lead, Chromium, Cobalt and Nickel to Photobacterium phosphoreum at No Observed Effect Concentration.

Journal: Bulletin of environmental contamination and toxicology
Published Date: Jun 2, 2015

Abstract

Joint toxicity of Pb2+, Cr3+, Co2+ and Ni2+ toward Photobacterium phosphoreum (Ph. phosphoreum) at the no observed effect concentration (NOEC) was determined through a factorial experiment. A neural network model was designed according to experimental results and employed for toxicity prediction of unary, binary, ternary and quaternary combinations. The mechanism and trends of joint toxicity were interpreted by quantitative structure-activity relationship, Michaelis-Menten kinetic model, and concentration addition (CA) theory. Toxicity was directly related to the covalent index (Xm2r), covalent binding reaction presented a first and zero order reaction at low and high concentration, respectively, and CA accurately predicted toxicity. Additionally, the results showed that low concentrations of heavy metals should be considered when conducting environment risk assessment.

Authors

  • Yaling Zeng
    Resources and Environmental Research Academy, North China Electric Power University, Beijing, 102206, China.
  • Lan Wang
    The Center of Psychosomatic Medicine, Sichuan Provincial Center for Mental Health, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu 611731, China.
  • Long Jiang
    Shanghai Lung Cancer Center, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai xxxx, China.
  • Xiaoyu Cai
  • Yu Li
    Department of Public Health, Shihezi University School of Medicine, 832000, China.

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