Magnetic nanoparticles and nanocomposites for remote controlled therapies.

Journal: Journal of controlled release : official journal of the Controlled Release Society
PMID: 26407670

Abstract

This review highlights the state-of-the-art in the application of magnetic nanoparticles (MNPs) and their composites for remote controlled therapies. Novel macro- to nano-scale systems that utilize remote controlled drug release due to actuation of MNPs by static or alternating magnetic fields and magnetic field guidance of MNPs for drug delivery applications are summarized. Recent advances in controlled energy release for thermal therapy and nanoscale energy therapy are addressed as well. Additionally, studies that utilize MNP-based thermal therapy in combination with other treatments such as chemotherapy or radiation to enhance the efficacy of the conventional treatment are discussed.

Authors

  • Anastasia K Hauser
    Department of Chemical and Materials Engineering, University of Kentucky, Lexington, KY 40506, USA.
  • Robert J Wydra
    Department of Chemical and Materials Engineering, University of Kentucky, Lexington, KY 40506, USA.
  • Nathanael A Stocke
    Department of Chemical and Materials Engineering, University of Kentucky, Lexington, KY 40506, USA.
  • Kimberly W Anderson
    Department of Chemical and Materials Engineering, University of Kentucky, Lexington, KY 40506, USA.
  • J Zach Hilt
    Department of Chemical and Materials Engineering, University of Kentucky, Lexington, KY 40506, USA. Electronic address: hilt@engr.uky.edu.

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