AIMC Topic: Nanoparticles

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High-throughput screening accelerated by machine learning for the morphology of silica nanoparticles with high cell permeability.

Nanoscale Aug 21, 2025
In recent years, silica nanoparticles have garnered tremendous attention as drug-delivery carriers. However, the cell permeability of nanoparticles remains a major obstacle that limits the drug-delivery efficiency of drug carriers. It is a common pra...
Humans Silicon Dioxide High-Throughput Screening Assays Machine Learning Cell Membrane Permeability Nanoparticles Drug Carriers
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Structural modification strategies for ferritin nanoparticles and their applications in biomedicine: a narrative review.

Nanoscale Jul 31, 2025
Ferritin is an iron-storage protein that naturally self-assembles into a hollow spherical particle consisting of 24 identical subunits, and it serves a central role in iron metabolism. Ferritin's favorable drug-loading capacity, biocompatibility, int...
Ferritins Metal Nanoparticles Neurodegenerative Diseases Humans Animals Nanoparticles Drug Delivery Systems
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Roadmap for Commercial Nanomedicine Development: Integrating Quality by Design Principles with Pharmaceutical Nanotechnology.

Molecular pharmaceutics Jul 16, 2025
Integrating Quality by Design (QbD) principles into nanomedicine development marks a paradigm shift from traditional empirical approaches to more systematic risk-based strategies. This review explores the application of QbD in pharmaceutical nanotech...
Humans Drug Delivery Systems Nanomedicine Drug Development Animals Nanotechnology Nanoparticles Liposomes
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Exploration of Predictive Potential of AI-enabled Portable System in Anticancer Drug Delivery: A Comparative Study with Modified Gompertz like Biphasic Response Model.

AAPS PharmSciTech Jul 16, 2025
Mathematical models are conventionally used to understand the of tumor behaviors, but they generally lack in precisely correlating drug efficacy with tumor response. Artificial intelligence (AI) has forged a new avenue in cancer management, but requi...
Cell Line, Tumor Mice Nanoparticles Animals Antineoplastic Agents Docetaxel Lipids Models, Biological Artificial Intelligence Algorithms Breast Neoplasms Drug Delivery Systems Female Humans
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A formulation dataset of poly(lactide-co-glycolide) nanoparticles for small molecule delivery.

Scientific data Jul 10, 2025
Poly(lactide-co-glycolide) (PLGA) nanoparticles are promising drug delivery systems, widely recognized for their ability to overcome various limitations associated with conventional formulations. However, designing and optimizing such formulations is...
Polylactic Acid-Polyglycolic Acid Copolymer Drug Delivery Systems Nanoparticles
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Optical Resolution of the Morphological Change of Single Nanoparticles at Native Conditions: A Nonsuper-Resolution Approach.

ACS sensors Jul 8, 2025
Label-free optical imaging of the morphology of single nanoparticles under native conditions remains a challenging task despite its importance in the synthesis, properties, and applications of nanomaterials. Here, we developed an angular scanning dar...
Nanoparticles Particle Size Microscopy Optical Imaging Machine Learning Metal Nanoparticles
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Recent advances of engineering cell membranes for nanomedicine delivery across the blood-brain barrier.

Journal of nanobiotechnology Jul 8, 2025
The blood-brain barrier (BBB) poses a major challenge to the effective delivery of therapeutic agents for the treatment of central nervous system (CNS) disorders. The integration of cell membrane engineering with nanotechnology has recently enabled t...
Humans Drug Delivery Systems Animals Blood-Brain Barrier Nanomedicine Nanoparticles Cell Membrane Central Nervous System Diseases
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Corona Dynamics of Nanoparticles and Their Functional Design Space in Molecular Sensing.

ACS nano Jul 6, 2025
As nanomaterials increasingly interact with complex biological environments, understanding and designing their interfacial layers is critical for enabling functional and responsive behaviors. The protein corona, a spontaneously formed biomolecular la...
Protein Corona Nanoparticles Adsorption Surface Properties Humans Biosensing Techniques
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Glycoproteomics Analysis to Identify Potential Biomarkers and Investigate CD14 Monocyte Activation Mechanisms via Exosomal Proteins in Cerebral Infarction Using a Novel Glycogen-Functionalized Nanoprobe.

Analytical chemistry Jul 3, 2025
Cerebral infarction (CI) is a leading cause of disability and mortality, with activated plasma monocytes and altered protein glycosylation identified as critical contributors to its pathology. However, the mechanisms linking peripheral monocyte activ...
Middle Aged Exosomes Biomarkers Proteomics Humans Female Glycoproteins Aged Nanoparticles Cerebral Infarction Male Lipopolysaccharide Receptors Monocytes
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Photoacoustic-Integrated Multimodal Approach for Colorectal Cancer Diagnosis.

ACS biomaterials science & engineering Jul 1, 2025
Colorectal cancer remains a major global health challenge, emphasizing the need for advanced diagnostic tools that enable early and accurate detection. Photoacoustic (PA) spectroscopy, a hybrid technique combining optical absorption with acoustic res...
Multimodal Imaging Colorectal Neoplasms Photoacoustic Techniques Humans Nanoparticles Machine Learning
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