Predicting target proteins for drug candidate compounds based on drug-induced gene expression data in a chemical structure-independent manner.

Journal: BMC medical genomics
PMID: 26684652

Abstract

BACKGROUND: Phenotype-based high-throughput screening is a useful technique for identifying drug candidate compounds that have a desired phenotype. However, the molecular mechanisms of the hit compounds remain unknown, and substantial effort is required to identify the target proteins associated with the phenotype.

Authors

  • Yoshiyuki Hizukuri
    Faculty of Exploratory Technology, Asubio Pharma Co. Ltd., 6-4-3 Minatojima-Minamimachi, Chuo-ku, Kobe, Hyogo, 650-0047, Japan. hizukuri.yoshiyuki.ms@asubio.co.jp.
  • Ryusuke Sawada
    Division of System Cohort, Multi-Scale Research Center for Medical Science, Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Fukuoka, 812-8582, Japan. rsawada@bioreg.kyushu-u.ac.jp.
  • Yoshihiro Yamanishi
    Division of System Cohort, Multi-Scale Research Center for Medical Science, Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Fukuoka, 812-8582, Japan. yamanishi@bioreg.kyushu-u.ac.jp.

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