Predicting MoRFs in protein sequences using HMM profiles.

Journal: BMC bioinformatics
Published Date: Dec 22, 2016

Abstract

BACKGROUND: Intrinsically Disordered Proteins (IDPs) lack an ordered three-dimensional structure and are enriched in various biological processes. The Molecular Recognition Features (MoRFs) are functional regions within IDPs that undergo a disorder-to-order transition on binding to a partner protein. Identifying MoRFs in IDPs using computational methods is a challenging task.

Authors

  • Ronesh Sharma
  • Shiu Kumar
    School of Electrical and Electronics Engineering, Fiji National University, Suva, Fiji.
  • Tatsuhiko Tsunoda
    Center for Integrative Medical Sciences, RIKEN Yokohama, Yokohama, 230-0045, Japan. tatsuhiko.tsunoda@riken.jp.
  • Ashwini Patil
    Human Genome Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan. ashwini@hgc.jp.
  • Alok Sharma
    Center for Integrative Medical Sciences, RIKEN Yokohama, Yokohama, 230-0045, Japan.

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