Grouping miRNAs of similar functions via weighted information content of gene ontology.

Journal: BMC bioinformatics
Published Date: Dec 22, 2016

Abstract

BACKGROUND: Regulation mechanisms between miRNAs and genes are complicated. To accomplish a biological function, a miRNA may regulate multiple target genes, and similarly a target gene may be regulated by multiple miRNAs. Wet-lab knowledge of co-regulating miRNAs is limited. This work introduces a computational method to group miRNAs of similar functions to identify co-regulating miRNAsfrom a similarity matrix of miRNAs.

Authors

  • Chaowang Lan
    School of Computer, Electronic and Information, and State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, Guangxi University, No.100 Daxue Road, Nanning, 530004, China.
  • Qingfeng Chen
    School of Computer, Electronic and Information, and State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, Guangxi University, No.100 Daxue Road, Nanning, 530004, China. qingfeng@gxu.edu.cn.
  • Jinyan Li

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