CIViC is a community knowledgebase for expert crowdsourcing the clinical interpretation of variants in cancer.

Journal: Nature genetics
PMID:

Abstract

CIViC is an expert-crowdsourced knowledgebase for Clinical Interpretation of Variants in Cancer describing the therapeutic, prognostic, diagnostic and predisposing relevance of inherited and somatic variants of all types. CIViC is committed to open-source code, open-access content, public application programming interfaces (APIs) and provenance of supporting evidence to allow for the transparent creation of current and accurate variant interpretations for use in cancer precision medicine.

Authors

  • Malachi Griffith
    The Genome Institute, Washington University in St. Louis, St. Louis, Missouri, United States of America; Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America.
  • Nicholas C Spies
    McDonnell Genome Institute, Washington University School of Medicine, St. Louis, Missouri, USA.
  • Kilannin Krysiak
    McDonnell Genome Institute, Washington University School of Medicine, St. Louis, Missouri, USA.
  • Joshua F McMichael
    The Genome Institute, Washington University in St. Louis, St. Louis, Missouri, United States of America.
  • Adam C Coffman
    The Genome Institute, Washington University in St. Louis, St. Louis, Missouri, United States of America.
  • Arpad M Danos
    McDonnell Genome Institute, Washington University School of Medicine, St. Louis, Missouri, USA.
  • Benjamin J Ainscough
    The Genome Institute, Washington University in St. Louis, St. Louis, Missouri, United States of America.
  • Cody A Ramirez
    McDonnell Genome Institute, Washington University School of Medicine, St. Louis, Missouri, USA.
  • Damian T Rieke
    Charité Comprehensive Cancer Center, Charité Universitätsmedizin, Berlin, Germany.
  • Lynzey Kujan
    McDonnell Genome Institute, Washington University School of Medicine, St. Louis, Missouri, USA.
  • Erica K Barnell
    McDonnell Genome Institute, Washington University School of Medicine, St. Louis, Missouri, USA.
  • Alex H Wagner
    McDonnell Genome Institute, Washington University School of Medicine, St. Louis, Missouri, USA.
  • Zachary L Skidmore
    The Genome Institute, Washington University in St. Louis, St. Louis, Missouri, United States of America.
  • Amber Wollam
    McDonnell Genome Institute, Washington University School of Medicine, St. Louis, Missouri, USA.
  • Connor J Liu
    McDonnell Genome Institute, Washington University School of Medicine, St. Louis, Missouri, USA.
  • Martin R Jones
    Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, British Columbia, Canada.
  • Rachel L Bilski
    McDonnell Genome Institute, Washington University School of Medicine, St. Louis, Missouri, USA.
  • Robert Lesurf
    McDonnell Genome Institute, Washington University School of Medicine, St. Louis, Missouri, USA.
  • Yan-Yang Feng
    McDonnell Genome Institute, Washington University School of Medicine, St. Louis, Missouri, USA.
  • Nakul M Shah
    McDonnell Genome Institute, Washington University School of Medicine, St. Louis, Missouri, USA.
  • Melika Bonakdar
    Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, British Columbia, Canada.
  • Lee Trani
    McDonnell Genome Institute, Washington University School of Medicine, St. Louis, Missouri, USA.
  • Matthew Matlock
    McDonnell Genome Institute, Washington University School of Medicine, St. Louis, Missouri, USA.
  • Avinash Ramu
    The Genome Institute, Washington University in St. Louis, St. Louis, Missouri, United States of America.
  • Katie M Campbell
    McDonnell Genome Institute, Washington University School of Medicine, St. Louis, Missouri, USA.
  • Gregory C Spies
    McDonnell Genome Institute, Washington University School of Medicine, St. Louis, Missouri, USA.
  • Aaron P Graubert
    McDonnell Genome Institute, Washington University School of Medicine, St. Louis, Missouri, USA.
  • Karthik Gangavarapu
    Department of Molecular and Experimental Medicine, Scripps Research Institute, La Jolla, California, USA.
  • James M Eldred
    The Genome Institute, Washington University in St. Louis, St. Louis, Missouri, United States of America.
  • David E Larson
    The Genome Institute, Washington University in St. Louis, St. Louis, Missouri, United States of America; Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America.
  • Jason R Walker
    The Genome Institute, Washington University in St. Louis, St. Louis, Missouri, United States of America.
  • Benjamin M Good
    Department of Molecular and Experimental Medicine, the Scripps Research Institute, La Jolla, CA, USA.
  • Chunlei Wu
    Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi, China.
  • Andrew I Su
    Department of Molecular and Experimental Medicine, the Scripps Research Institute, La Jolla, CA, USA.
  • Rodrigo Dienstmann
    Oncology Data Science Group, Vall d'Hebron Institute of Oncology, Barcelona, Spain.
  • Adam A Margolin
    Computational Biology, Oregon Health and Science University, Portland, Oregon, USA.
  • David Tamborero
    Institute for Research in Biomedicine, Barcelona Institute of Science and Technology, Barcelona, Spain.
  • Nuria Lopez-Bigas
    Institute for Research in Biomedicine, Barcelona Institute of Science and Technology, Barcelona, Spain.
  • Steven J M Jones
    Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, British Columbia, Canada.
  • Ron Bose
    Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
  • David H Spencer
    McDonnell Genome Institute, Washington University School of Medicine, St. Louis, Missouri, USA.
  • Lukas D Wartman
    McDonnell Genome Institute, Washington University School of Medicine, St. Louis, Missouri, USA.
  • Richard K Wilson
    The Genome Institute, Washington University in St. Louis, St. Louis, Missouri, United States of America; Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America; Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America; Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri, United States of America; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, United States of America.
  • Elaine R Mardis
    The Genome Institute, Washington University in St. Louis, St. Louis, Missouri, United States of America; Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America; Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America; Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri, United States of America; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, United States of America.
  • Obi L Griffith
    The Genome Institute, Washington University in St. Louis, St. Louis, Missouri, United States of America; Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America.