Prior knowledge guided active modules identification: an integrated multi-objective approach.

Journal: BMC systems biology
PMID: 28361699

Abstract

BACKGROUND: Active module, defined as an area in biological network that shows striking changes in molecular activity or phenotypic signatures, is important to reveal dynamic and process-specific information that is correlated with cellular or disease states.

Authors

  • Weiqi Chen
    School of Computer Science, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.
  • Jing Liu
    Department of Ophthalmology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
  • Shan He
    Key Laboratory of Applied Marine Biotechnology, Ningbo University, Ningbo 315211, China. Electronic address: heshan@nbu.edu.cn.

Keywords

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