Very Deep Convolutional Neural Networks for Morphologic Classification of Erythrocytes.

Journal: Clinical chemistry
Published Date:

Abstract

BACKGROUND: Morphologic profiling of the erythrocyte population is a widely used and clinically valuable diagnostic modality, but one that relies on a slow manual process associated with significant labor cost and limited reproducibility. Automated profiling of erythrocytes from digital images by capable machine learning approaches would augment the throughput and value of morphologic analysis. To this end, we sought to evaluate the performance of leading implementation strategies for convolutional neural networks (CNNs) when applied to classification of erythrocytes based on morphology.

Authors

  • Thomas J S Durant
    Department of Laboratory Medicine, Yale School of Medicine, New Haven, CT.
  • Eben M Olson
    Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT.
  • Wade L Schulz
    Department of Laboratory Medicine, Yale School of Medicine, New Haven, CT.
  • Richard Torres
    Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT. richard.torres@yale.edu.