A method for optical imaging and monitoring of the excretion of fluorescent nanocomposites from the body using artificial neural networks.

Journal: Nanomedicine : nanotechnology, biology, and medicine
PMID: 29655916

Abstract

In this study, a new approach to the implementation of optical imaging of fluorescent nanoparticles in a biological medium using artificial neural networks is proposed. The studies were carried out using new synthesized nanocomposites - nanometer graphene oxides, covered by the poly(ethylene imine)-poly(ethylene glycol) copolymer and by the folic acid. We present an example of a successful solution of the problem of monitoring the removal of nanocomposites based on nGO and their components with urine using fluorescent spectroscopy and artificial neural networks. However, the proposed method is applicable for optical imaging of any fluorescent nanoparticles used as theranostic agents in biological tissue.

Authors

  • Olga E Sarmanova
    Lomonosov Moscow State University, Physical Department, Moscow, Russia. Electronic address: oe.sarmanova@physics.msu.ru.
  • Sergey A Burikov
    Lomonosov Moscow State University, Physical Department, Moscow, Russia; Skobeltsyn Institute of Nuclear Physics, Lomonosov Moscow State University, Moscow, Russia. Electronic address: sergey.burikov@gmail.com.
  • Sergey A Dolenko
    Skobeltsyn Institute of Nuclear Physics, Lomonosov Moscow State University, Moscow, Russia. Electronic address: dolenko@srd.sinp.msu.ru.
  • Igor V Isaev
    Lomonosov Moscow State University, Physical Department, Moscow, Russia; Skobeltsyn Institute of Nuclear Physics, Lomonosov Moscow State University, Moscow, Russia. Electronic address: isaev_igor@mail.ru.
  • Kirill A Laptinskiy
    Lomonosov Moscow State University, Physical Department, Moscow, Russia; Skobeltsyn Institute of Nuclear Physics, Lomonosov Moscow State University, Moscow, Russia. Electronic address: laptinskij@physics.msu.ru.
  • Neeraj Prabhakar
    Pharmaceutical Sciences Laboratory, Faculty of Science and Engineering, Åbo Akademi University, Turku, Finland. Electronic address: neepra@utu.fi.
  • Didem Şen Karaman
    Pharmaceutical Sciences Laboratory, Faculty of Science and Engineering, Åbo Akademi University, Turku, Finland. Electronic address: didem.sen@abo.fi.
  • Jessica M Rosenholm
    Pharmaceutical Sciences Laboratory, Faculty of Science and Engineering, Åbo Akademi University, Turku, Finland. Electronic address: jessica.rosenholm@abo.fi.
  • Olga A Shenderova
    Adámas Nanotechnologies, Inc., Raleigh, North Carolina, United States. Electronic address: oshenderova@itc-inc.org.
  • Tatiana A Dolenko
    Lomonosov Moscow State University, Physical Department, Moscow, Russia; Skobeltsyn Institute of Nuclear Physics, Lomonosov Moscow State University, Moscow, Russia. Electronic address: tdolenko@lid.phys.msu.ru.

Keywords

External Resources

Popular Topics
Recent Journals