Reactome diagram viewer: data structures and strategies to boost performance.

Journal: Bioinformatics (Oxford, England)
Published Date: Apr 1, 2018

Abstract

MOTIVATION: Reactome is a free, open-source, open-data, curated and peer-reviewed knowledgebase of biomolecular pathways. For web-based pathway visualization, Reactome uses a custom pathway diagram viewer that has been evolved over the past years. Here, we present comprehensive enhancements in usability and performance based on extensive usability testing sessions and technology developments, aiming to optimize the viewer towards the needs of the community.

Authors

  • Antonio Fabregat
    European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton CB10 1SD, UK.
  • Konstantinos Sidiropoulos
    European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton CB10 1SD, UK.
  • Guilherme Viteri
    European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton CB10 1SD, UK.
  • Pablo Marin-Garcia
    Fundación Investigación INCLIVA, Universitat de València, Valencia, Spain.
  • Peipei Ping
    From the NIH BD2K Center of Excellence for Biomedical Computing at UCLA, Los Angeles, CA (P.P., K.W., A.B.); and NIH BD2K KnowEng Center of Excellence for Biomedical Computing at UIUC, Urbana, IL (J.H.). pping38@g.ucla.edu.
  • Lincoln Stein
    Informatics and Bio-computing, Ontario Institute for Cancer Research, Toronto, Ontario, Canada.
  • Peter D'Eustachio
    Department of Biochemistry & Molecular Pharmacology, NYU. Langone Medical Center, New York, NY, United States.
  • Henning Hermjakob
    European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.

Keywords

External Resources

Popular Topics
Recent Journals