Extending the DIDEO ontology to include entities from the natural product drug interaction domain of discourse.

Journal: Journal of biomedical semantics
Published Date: May 9, 2018

Abstract

BACKGROUND: Prompted by the frequency of concomitant use of prescription drugs with natural products, and the lack of knowledge regarding the impact of pharmacokinetic-based natural product-drug interactions (PK-NPDIs), the United States National Center for Complementary and Integrative Health has established a center of excellence for PK-NPDI. The Center is creating a public database to help researchers (primarly pharmacologists and medicinal chemists) to share and access data, results, and methods from PK-NPDI studies. In order to represent the semantics of the data and foster interoperability, we are extending the Drug-Drug Interaction and Evidence Ontology (DIDEO) to include definitions for terms used by the data repository. This is feasible due to a number of similarities between pharmacokinetic drug-drug interactions and PK-NPDIs.

Authors

  • John Judkins
    Department of Biomedical Informatics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
  • Jessica Tay-Sontheimer
    School of Pharmacy, University of Washington, Seattle, WA, USA.
  • Richard D Boyce
    Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, PA, USA.
  • Mathias Brochhausen
    Department of Biomedical Informatics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.

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