Pharmacokinetic Therapeutic Drug Monitoring of Advagraf in More Than 500 Adult Renal Transplant Patients, Using an Expert System Online.

Journal: Therapeutic drug monitoring
Published Date: Jun 1, 2018

Abstract

BACKGROUND: Immunosuppressant Bayesian dose adjustment (ISBA) is an online expert system, routinely used by approximately 140 transplantation centers in the world for the dose adjustment of immunosuppressive drugs in transplant patients. This system determines the area under the curve (AUC) of the drug by pharmacokinetic modeling and Bayesian estimation. The purpose of this study was to analyze tacrolimus exposure after administration of its modified-release formulation (Advagraf) in kidney allograft recipients, to optimize its therapeutic drug monitoring.

Authors

  • Pierre Marquet
    University of Limoges, UMR 1248.
  • Anne Bedu
    University of Limoges, UMR 1248.
  • Caroline Monchaud
    INSERM, U1248.
  • Franck Saint-Marcoux
    University of Limoges, UMR 1248.
  • Jean-Philippe Rérolle
    FHU SUPORT.
  • Isabelle Etienne
    Department of Nephrology, University Hospital, Rouen, France.
  • Nassim Kamar
    Department of Nephrology and Organ Transplantation, CHU Rangueil, Toulouse, France.
  • Bruno Moulin
    Department of Nephrology and Transplantation, University Hospital of Strasbourg, Strasbourg, France.
  • Elisabeth Cassuto
    Transplant Unit, University Hospital, Nice, France.
  • Marie Essig
    Service de néphrologie et transplantation rénale, CHU Dupuytren, Limoges, France.
  • Jean-Baptiste Woillard
    P&T, Unité Mixte de Recherche 1248 Université de Limoges, Institut National de la Santé et de la Recherche Médicale, Limoges, France.

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