Protein threading using residue co-variation and deep learning.

Journal: Bioinformatics (Oxford, England)
Published Date: Jul 1, 2018

Abstract

MOTIVATION: Template-based modeling, including homology modeling and protein threading, is a popular method for protein 3D structure prediction. However, alignment generation and template selection for protein sequences without close templates remain very challenging.

Authors

  • Jianwei Zhu
    College of Food Science and Engineering, Jilin Agricultural University, Changchun 130118, China.
  • Sheng Wang
    Intensive Care Medical Center, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, People's Republic of China.
  • Dongbo Bu
    Key Lab of Intelligent Information Process, Institute of Computing Technology, Chinese Academy of Sciences, Beijing, China.
  • Jinbo Xu
    Toyota Technological Institute at Chicago, Chicago, IL 60615, USA.

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